Antennova Unveils Promising ATN-037 Data at ESMO Congress 2024
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Antennova to Showcase ATN-037 at ESMO Congress 2024
Antennova, a pioneering biotech company specializing in oncology, will present the latest data regarding its small molecule inhibitor ATN-037 during a Mini Oral presentation at the upcoming European Society of Medical Oncology Congress 2024. This prestigious event is set to occur in Barcelona, bringing together key players in the oncology field.
Presentation Highlights
The presentation will primarily focus on the ongoing Phase I/Ib study of ATN-037, also referred to as ATG-037. This inhibitor targets CD73, and the study is exploring its application both as a monotherapy and in combination with pembrolizumab, a well-known anti-PD-1 therapy. The objective is to evaluate the drug’s safety, pharmacokinetics, and optimal dosage in patients battling advanced solid tumors.
Study Overview
The study, called STAMINA-01, holds significant promise for patients who have seen little success from existing treatments. ATN-037 is touted for its potent ability to hinder CD73, a contributor to tumor immune evasion. Data from the trial thus far indicates a hopeful outlook for its efficacy.
Key Details of the Research
The Mini Oral session at the ESMO Congress will feature critical insights into ATN-037’s performance:
- Abstract Number: 6067
- Presentation Number: 997MO
- Date and Time: Scheduled for September 16, 2024, at 10:50 AM CEST
Efficacy and Safety Observations
As of early 2024, 32 patients were enrolled in the trial, showcasing a range of dosages administered from 20mg to 600mg of ATN-037. Notably, among the patients treated, a disease control rate of 43.8% was observed within the monotherapy cohort, illustrating a positive outcome. The combination therapy group exhibited a 20% overall response rate, demonstrating ATN-037's potential effectiveness in treating resistant tumors.
Future Directions
Antennova continues to push forward with its research ambitions. Currently, they are optimizing dosage levels and expanding the trial's scope further into new regions, including plans to initiate studies in an Asian market by the end of the year.
About Antennova
Antennova is a Delaware corporation and operates as a subsidiary of Antengene. This company is committed to developing groundbreaking therapies aimed at critical biological mechanisms that help tumors resist traditional treatments. Their pipeline includes various promising candidates, with ATN-037 being one of the leading drugs aimed at overcoming challenges in cancer treatments.
Frequently Asked Questions
What is ATN-037?
ATN-037 is a small molecule inhibitor targeting CD73, intended to enhance the effectiveness of cancer treatments.
What studies are being conducted on ATN-037?
A Phase I/Ib study, STAMINA-01, is currently evaluating ATN-037 both as a monotherapy and in combination with pembrolizumab.
When will the results of the study be presented?
The latest data will be presented at the ESMO Congress on September 16, 2024.
What kind of cancers is ATN-037 targeting?
ATN-037 is being studied for its effects on advanced solid tumors, particularly in patients with refractory/relapsed conditions.
What are the next steps for Antennova?
Antennova aims to optimize dosing and expand trials internationally, including initiatives in Asian markets.
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