Annexon to Showcase ANX007 Efficacy in Protecting Vision

Annexon to Present Phase 2 ARCHER Findings on Vision Protection

At the upcoming Floretina-ICOOR 2024 meeting, Annexon, Inc. will share significant findings regarding its innovative therapy, ANX007. This presentation is particularly exciting for those affected by geographic atrophy (GA), a condition that leads to vision loss. With the notable achievement of demonstrating substantial vision protection in various lighting conditions, ANX007 stands out as a pioneering treatment.

Conference Details and Presentations

Taking place in Florence, Italy, from December 5-8, this conference will see experts reveal in-depth analyses derived from the Phase 2 ARCHER trial. The details of the presentations reflect a commitment to understanding both the structural and functional preservation of vision through C1q inhibition.

Key Presentations Highlighting ANX007

One of the highlights will be a podium presentation by Dr. Jeffrey S. Heier, focusing on unlocking the structure/function relationships in geographic atrophy. This share will delve into the ways ANX007 enhances visual acuity protection through targeted intervention.

Dr. Paulo Eduardo Stanga will also present vital findings regarding the prevention of visual acuity loss and the preservation of essential photoreceptors in patients receiving ANX007 treatment. The anticipated outcomes promise to shed light on navigating the complexities of dry age-related macular degeneration (AMD) and geographic atrophy.

Special Symposium on Vision Protection

Annexon is hosting a symposium entitled, "Protection of Vision and Structure in GA," which will feature expert discussions from leading researchers such as Dr. Peter Kaiser and Dr. Charles C. Wykoff. These experts will discuss the impacts of C1q on neurodegeneration and the significant safety profile of ANX007.

Understanding ANX007 and Its Mechanism

ANX007 represents a first-in-class treatment designed as an antigen-binding fragment (Fab) that targets C1q, a critical player in the classical complement pathway. This pathway, when improperly activated, contributes to neurodegenerative processes prevalent in diseases like geographic atrophy. By inhibiting C1q, ANX007 aims to mitigate synapse loss and inflammation, providing a potential lifeline for patients experiencing vision loss due to GA.

Trial Results and Future Directions

The Phase 2 ARCHER trial demonstrated encouraging outcomes, with ANX007 providing statistically significant protection against vision loss across numerous parameters. Patients receiving the treatment exhibited improvements in visual acuity and overall visual function. The hope following these results is that ANX007 could pave the way for therapeutic advancements within the broader retinal disease treatment landscape.

The Broader Impact of Geographic Atrophy

Geographic atrophy currently threatens the vision of millions, representing a chronic progressive disorder of the retina that often leads to profound emotional and social challenges for those affected. With nearly one million people in the United States and eight million globally impacted by this illness, solutions are direly needed. Existing treatments have yet to offer effective means to halt progression and loss of vision.

Looking Forward to Phase 3 ARCHER II Trial

As Annexon advances to the Phase 3 ARCHER II trial, the hope is to enroll approximately 630 patients to evaluate ANX007 against sham treatment. With a focus on establishing significant prevention of visual acuity loss, this trial will assess both the immediate and long-term impact of the treatment. Data collection is anticipated throughout the next few years, aiming to solidify ANX007's role as a groundbreaking therapeutic option.

About Annexon and Their Vision

Annexon Biosciences is on a mission to redefine treatment options for patients battling serious neuroinflammatory diseases affecting the body, brain, and eyes. Their unique approach focuses on addressing the root cause of neurodegeneration by targeting C1q, aiming to transform the lives of over 8 million individuals across the globe. Their commitment to delivering innovative therapies seeks to empower patients to lead fulfilling lives.

Frequently Asked Questions

What is ANX007?

ANX007 is a first-in-class therapy targeting C1q to protect vision in patients with geographic atrophy (GA) by blocking neurodegenerative processes.

Where will the presentations be held?

The presentations will be part of the Floretina-ICOOR 2024 meeting held in Florence, Italy, from December 5 to December 8.

What were the results of the Phase 2 ARCHER trial?

The Phase 2 ARCHER trial indicated that ANX007 provided significant protection against vision loss and retained benefits during a follow-up period.

How many patients will be enrolled in the ARCHER II trial?

Approximately 630 patients with geographic atrophy will be enrolled in the global ARCHER II trial.

Why is targeting C1q important?

Targeting C1q is crucial as it initiates the classical complement pathway, leading to neuroinflammation and vision loss; inhibiting it provides a unique therapeutic strategy.

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