New Findings from the REDUCE-IT Study
Amarin Corporation plc (NASDAQ:AMRN) has made significant strides in cardiovascular health research, presenting new subgroup data from the influential REDUCE-IT cardiovascular outcomes trial involving VASCEPA/VAZKEPA (icosapent ethyl). These important findings will be showcased at the European Society of Cardiology (ESC) Congress, aimed at elevating the scientific understanding of cardiovascular risks.
Key Subgroup Data
The presented subgroup analysis explores how baseline small dense low-density lipoprotein cholesterol (sdLDL-C) levels influence the efficacy of icosapent ethyl on cardiovascular events. This pivotal research sheds light on the relationship between sdLDL-C and cardiovascular health, aiding clinicians in tailoring treatment plans for at-risk patients.
Mechanistic Insights into Eicosapentaenoic Acid (EPA)
In addition to subgroup data, researchers will present abstract findings showcasing the mechanistic role of eicosapentaenoic acid (EPA). A variety of studies will be discussed, including the correlation between triglyceride levels and cardiovascular incidents in patients with acute coronary syndrome (ACS), alongside estimates of eligible patients for treatment in hospitals.
Presentations at ESC Congress 2024
Several significant presentations will take place, including:
- Icosapent Ethyl by Baseline Small Dense Low-Density Lipoprotein Cholesterol - An analysis detailing the influence of sdLDL-C on treatment outcomes. Scheduled for August 30.
- Effect of Triglycerides on Cardiovascular Risk - Exploring the impact of triglyceride levels on ACS outcomes on September 2.
- Candidate Prognosis for Eicosapentaenoic Acid Treatment Post-ACS - Discussed on September 2, this study assesses potential patient candidates following ACS.
- High Glucose Effects on Lipoprotein(a) Oxidation - Investigating the biochemical interactions of EPA with Lp(a) oxidation scheduled for September 2.
Commitment to Cardiovascular Research
Amarin emphasizes its commitment to advancing cardiovascular care through research. The company focuses on residual cardiovascular risks that persist beyond traditional lipid management methods, aspiring to enhance patient outcomes. Nabil Abadir, SVP, Chief Medical Officer, expressed that the findings presented at the ESC will deepen the clinical understanding of elevated triglyceride impacts and the potential of VASCEPA/VAZKEPA.
About Amarin Corporation
Amarin is an innovative pharmaceutical entity driving a paradigm shift in cardiovascular disease management. With a global outlook, it operates from offices in several international locations and aims to elevate understanding and treatment of cardiovascular risks.
Overview of REDUCE-IT Study
The REDUCE-IT study is a landmark global trial aimed at assessing VASCEPA’s efficacy in lowering cardiovascular events in adults receiving statin therapy. Following 8,179 patients across numerous clinical sites, the study focused on adults with controlled LDL-C but elevated triglycerides, culminating in substantial findings on cardiovascular disease management.
VASCEPA Overview
VASCEPA (icosapent ethyl) capsules represent a breakthrough in prescribed medications by targeting high cardiovascular risk categories. Regarded as the first FDA-approved treatment solely comprising icosapent ethyl, VASCEPA launched in the United States aims to mitigate cardiovascular complication risks.
Indications and Safety Information
VASCEPA is indicated for use alongside statin therapy to reduce myocardial infarction and stroke risk among patients with elevated triglyceride levels. The medication is also prescribed for reducing triglyceride levels in adults experiencing severe hypertriglyceridemia. It is vital for practitioners to weigh potential risks associated with VASCEPA, including increased risks of atrial fibrillation and bleeding.
Contact Information
For further inquiries regarding VASCEPA or Amarin, media and investor contacts are as follows:
Mark Marmur
Amarin Corporation plc
PR@amarincorp.com
Frequently Asked Questions
What is the REDUCE-IT study?
The REDUCE-IT study is a pivotal clinical trial investigating the effectiveness of VASCEPA in reducing cardiovascular events among patients with high triglyceride levels.
Where will the results be presented?
The results will be presented at the European Society of Cardiology (ESC) Congress, fostering greater understanding in the cardiovascular field.
What is VASCEPA?
VASCEPA (icosapent ethyl) is a prescription medication approved by the FDA aimed at lowering the risk of cardiovascular events in patients with elevated triglyceride levels.
Who can benefit from VASCEPA?
Patients with cardiovascular conditions or those at risk with elevated triglycerides may benefit from VASCEPA as part of their treatment regimen.
What are the common side effects of VASCEPA?
Common adverse reactions reported include musculoskeletal pain, peripheral edema, constipation, and increased risk of atrial fibrillation or bleeding.
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