ALX Oncology Unveils Promising Data on CD47 and HER2+ Cancer

ALX Oncology's Exciting Study Update

ALX Oncology Holdings Inc. (NASDAQ: ALXO), a trailblazer in the biotechnology sector, is making significant strides in cancer treatment through its innovative research. The company recently announced updated findings from the Phase 2 ASPEN-06 trial, which highlight the role of CD47 overexpression as a critical predictive biomarker for patients with HER2-positive gastric cancer.

Understanding the ASPEN-06 Trial

The ASPEN-06 trial is designed to evaluate the effectiveness of ALX Oncology's leading candidate, evorpacept, in combination with HERCEPTIN and CYRAMZA, alongside paclitaxel. This clinical trial aims to explore treatment options for patients suffering from advanced forms of HER2-positive gastric cancer and gastroesophageal junction (GEJ) cancer who have not previously responded to other therapies.

Key Highlights from the Presentation

During the upcoming Society for Immunotherapy of Cancer (SITC) 40th Annual Meeting, ALX Oncology will present crucial data from the trial. The poster presentation will take place on November 8, featuring Dr. Zev A. Wainberg as the first author. The focus will be on how CD47 expression can forecast therapeutic responses to evorpacept, a step forward in personalized medicine.

Trial Details and Patient Enrollment

The ASPEN-06 study is an open-label and randomized trial encompassing a diverse, international patient pool. Specifically, 127 adult patients were enrolled to assess the combination therapy's efficacy, targeting a demographic in dire need of innovative treatment options.

About Evorpacept and Its Potential

Evorpacept stands out as a potential cornerstone therapy in the immune-oncology landscape, signifying ALX Oncology's commitment to advancing patient care. With ongoing trials evaluating its application across various cancer types, evorpacept’s innovative approach could redefine treatment paradigms in oncology.

ALX Oncology's Continuing Journey

As a clinical-stage biotechnology company, ALX Oncology is not only focusing on evorpacept but also exploring other therapeutic candidates in its pipeline, including ALX2004, a unique EGFR-targeted antibody-drug conjugate. This candidate entered clinical trials, showcasing the company’s dedication to expanding its arsenal against cancer.

Building a Community of Hope

ALX Oncology aims to create a community around its research, involving healthcare professionals, patients, and advocates. By actively sharing data and insights, ALX Oncology fosters a collaborative atmosphere that emphasizes improving patient outcomes.

Investing in the Future of Oncology

With robust research initiatives and promising clinical data, ALX Oncology illustrates the vital connection between innovative therapies and patient survival rates. Investors keen on biotechnology advancements will find ALX Oncology's trajectory noteworthy as it continues to unveil critical findings and expand its pipeline.

Frequently Asked Questions

What is the significance of CD47 in the ASPEN-06 trial?

CD47 overexpression serves as a predictive biomarker for therapeutic responses in patients with HER2-positive gastric cancer, crucial for tailoring treatment.

Who is leading the ASPEN-06 trial?

Dr. Zev A. Wainberg, a prominent figure in the oncology field, is the first author of the upcoming presentation on the trial's findings.

What therapies are being evaluated in the ASPEN-06 trial?

The trial focuses on evorpacept in combination with HERCEPTIN, CYRAMZA, and paclitaxel for treating advanced gastric and GEJ cancer.

How many patients were enrolled in the trial?

A total of 127 adult patients participated in the Phase 2 portion of the ASPEN-06 trial.

What other programs is ALX Oncology exploring?

ALX Oncology is advancing not only evorpacept but also ALX2004, an EGFR-targeted antibody-drug conjugate, in clinical trials.

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