Alumis Showcases A-005's Promise for Neurodegenerative Treatments

Alumis Unveils Promising Phase 1 Data on A-005

Alumis Inc. (Nasdaq: ALMS), a clinical stage biopharmaceutical innovator based in South San Francisco, has made strides in the field of neuroinflammatory and neurodegenerative diseases. Recently, the company announced it will present significant findings regarding A-005, a CNS penetrant TYK2 inhibitor, during the upcoming ACTRIMS Forum.

Data Presentation Highlights

At the ACTRIMS Forum, taking place in late February, Alumis will host two critical presentations that highlight the capabilities of A-005. Renowned for its potent inhibition of TYK2 signaling pathways in immune cells, A-005 aims to provide targeted treatment options for complex neuroinflammatory conditions.

Expert Insights on A-005

Dr. Jörn Drappa, the Chief Medical Officer at Alumis, shared key insights regarding the data. He emphasized that A-005 showcases impressive potency in inhibiting TYK2-specific pathways that contribute to neuroinflammation. This innovative approach, marking A-005 as the first allosteric TYK2 inhibitor with the ability to cross the blood-brain barrier, stands as a potential breakthrough in treating these challenging diseases.

Phase 1 Clinical Trial Findings

The Phase 1 clinical trial involving A-005 has yielded compelling results, demonstrating that the compound is well-tolerated across a range of doses while effectively achieving maximal TYK2 inhibition. These findings have energized the team at Alumis, setting the stage for a Phase 2 trial slated for later this year, focusing on patients living with multiple sclerosis.

Poster Presentation Details

The key presentations on A-005 at the ACTRIMS Forum are scheduled as follows:

• Title: A-005, a Selective Oral Brain Penetrant TYK2 Inhibitor, Modulates Astrocytes and Microglia
  Poster Number: P352
  Time: 6:00 PM – 6:45 PM ET
• Title: Safety, Tolerability, and Pharmacokinetics of A-005: A Selective Brain-Penetrant TYK2 Inhibitor for CNS Inflammatory Diseases in Healthy Volunteers Following Single and Multiple Ascending Doses
  Poster Number: P335
  Time: 6:45 PM – 7:30 PM ET

Alumis encourages interested parties to access the ACTRIMS Forum 2025 presentations, set to be available on their website following the event.

About the A-005 Development Program

A-005 is a forward-thinking therapeutic option in development to address various neuroinflammatory and neurodegenerative conditions, including multiple sclerosis and Parkinson’s Disease. Its unique formulation aims to ensure effective TYK2 inhibition while penetrating the CNS, promising enhanced treatment efficacy.

About Alumis

Alumis stands at the forefront of biopharmaceutical innovation, dedicated to crafting oral therapies that leverage precision data analytics to significantly uplift patient outcomes. Currently, the company’s pipeline includes ESK-001, a selective TYK2 inhibitor under evaluation for autoimmune conditions, alongside A-005. The vision of Alumis is to pioneer drug development that fundamentally transforms the management of immune-mediated diseases through its innovative approach.

Frequently Asked Questions

What is A-005?

A-005 is a novel CNS penetrant TYK2 inhibitor developed by Alumis, aiming to treat neuroinflammatory diseases.

What were the main findings of the Phase 1 trial for A-005?

The trial indicated that A-005 was well-tolerated and effectively maximized TYK2 inhibition across a variety of doses.

When is the Phase 2 trial of A-005 expected to begin?

The Phase 2 clinical trial for A-005 is expected to commence in the latter half of the year.

What diseases is A-005 targeting?

A-005 is being developed for neuroinflammatory and neurodegenerative diseases, including multiple sclerosis and Parkinson’s Disease.

How does Alumis use precision data analytics?

Alumis employs a proprietary platform to guide the development of oral therapies, focusing on optimizing clinical outcomes for patients with immune-mediated conditions.

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