Aligos Therapeutics Showcases Breakthrough Results at TLM 2024

Aligos Therapeutics Highlights Promising Data at TLM 2024

Aligos Therapeutics, Inc. (NASDAQ: ALGS), a focused biopharmaceutical company based in South San Francisco, recently presented groundbreaking results at the renowned The Liver Meeting (TLM) 2024, hosted by the American Association for the Study of Liver Diseases. Throughout the event, the company shared findings from a late-breaker oral presentation and three compelling poster presentations, giving a glimpse into the future of therapies aimed at liver and viral diseases.

Impressive Results from ALG-000184

Innovation Against Chronic Hepatitis B

The poster presentations were dominated by promising findings related to ALG-000184, a novel antiviral treatment for chronic hepatitis B (CHB). This compound has shown impressive efficacy among both HBeAg-positive and HBeAg-negative patients. Data displayed from a study involving daily doses of 300 mg illustrated that 100% of HBeAg-positive patients maintained HBV DNA suppression throughout the treatment duration, demonstrating the medication's potent antiviral properties.

Furthermore, those HBeAg-negative subjects also reported successful suppression results, with an outstanding percentage achieving sustained HBV DNA levels below the level of quantification (LLOQ). No cases of viral resistance were noted, which is a significant consideration for ongoing treatment protocols.

Progress with ALG-055009 in MASH

Effective Reductions in Liver Fat Content

Aligos Therapeutics didn't stop with hepatitis B; the late-breaker presentation also featured ALG-055009, a promising THR-? agonist designed explicitly for metabolic dysfunction-associated steatohepatitis (MASH). In a study involving 12 weeks of treatment, patients exhibited substantial reductions in liver fat content, validating ALG-055009's potential as a best-in-class therapy.

With dosages adjusted between 0.5 mg and 0.9 mg, patients showcased placebo-adjusted median relative reductions of up to 46.2% in liver fat. This metric not only suggests a robust therapeutic effect but also points towards the possibility of significant histological improvements in conditions related to liver health.

Clinical Implications and Company Insights

Voicing Confidence in Future Therapies

Lawrence Blatt, PhD, MBA, Chairman, President, and CEO of Aligos Therapeutics expressed optimism regarding the findings. He stated that the data from ALG-000184 reaffirms the therapy's potential as a first-line treatment for chronic hepatitis B and its possible role in next-generation regimens aimed at achieving a functional cure.

Additionally, the favorable results from ALG-055009 could pave the way for revolutionary treatments in metabolic health, particularly for patients already undergoing GLP-1 agonist therapy. With significant lipoprotein reductions, ALG-055009 emerged as a contender in addressing cardiovascular risk factors associated with liver dysfunction.

About Aligos Therapeutics

Aligos Therapeutics is dedicated to enhancing patient outcomes via innovative therapies targeting liver and viral diseases. The organization prides itself on leveraging extensive research and development capabilities to address high unmet medical needs. With a solid strategy centered around its growing portfolio, Aligos is poised to make a substantial impact in the pharmaceutical landscape.

Frequently Asked Questions

What is Aligos Therapeutics known for?

Aligos Therapeutics, Inc. is focused on developing innovative therapies for liver and viral diseases, with a special emphasis on chronic hepatitis B and metabolic dysfunction-associated steatohepatitis.

What notable results were presented at TLM 2024?

Prominent findings from TLM 2024 included data showcasing the efficacy of ALG-000184 in chronic hepatitis B and ALG-055009 in reducing liver fat content for MASH patients.

How does ALG-000184 work?

ALG-000184 acts as an antiviral treatment targeting chronic hepatitis B virus infection, showing substantial viral suppression rates without the development of resistance.

What conditions does ALG-055009 address?

ALG-055009 is designed to treat metabolic dysfunction-associated steatohepatitis (MASH), aiming to reduce liver fat and improve overall liver health.

How is Aligos Therapeutics planning to move forward after these findings?

Aligos plans to continue its research and development of these promising therapies, aiming to enhance treatment options for liver and viral diseases while closely monitoring patient outcomes.

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