Akeso's Cadonilimab and Ivonescimab Added to National Drug List

Akeso Celebrates Inclusion of Cadonilimab and Ivonescimab

Akeso, Inc. (9926.HK) is excited to share the news that two of its groundbreaking bispecific antibody drugs—cadonilimab Injection and ivonescimab Injection—have been added to the latest National Reimbursement Drug List (NRDL) by China's National Healthcare Security Administration. This significant development will take effect shortly, marking a new era for patient access to cutting-edge therapies.

Impact of Inclusion in the National Reimbursement Drug List

The inclusion of these therapies in the NRDL highlights the crucial role they will play in treating specific cancers. Cadonilimab is approved for patients with relapsed or metastatic cervical cancer who have shown progression after chemotherapy. Meanwhile, ivonescimab is indicated for locally advanced or metastatic non-small cell lung cancer with specific EGFR mutations. This strategic move by the Chinese healthcare system aims to open doors to advanced treatments for a broader audience.

The Role of Healthcare Insurance in China

China's healthcare insurance structure, which includes basic medical, maternity, and work-related injury coverage, reaches more than 95% of the population. Medications listed in the NRDL receive funding support that greatly influences procurement processes within hospitals. Recent statistics underline that in a given year, almost 90% of hospital drug procurement orders are attributed to drugs falling under the NRDL’s umbrella, thus underscoring the importance of including innovative medicines in the list.

Dr. Xia Yu's Perspective

Dr. Xia Yu, the visionary behind Akeso, expressed her enthusiasm regarding this development. She noted, "The addition of these biologics to the NRDL signifies a pivotal moment for cancer treatment accessibility. Our priority is clear: to lessen the financial strain on cancer patients and empower them to access world-class therapeutic options that have been scientifically validated."

Understanding Cadonilimab and its Benefits

Cadonilimab represents a notable first in cancer immunotherapy, expertly targeting both PD-1 and CTLA-4 to maximize therapeutic benefits. This innovative approach shows considerable promise, particularly for patients with advanced cervical cancer who may have had limited options. Data demonstrate that cadonilimab provides significant clinical advantages, including a robust median overall survival of more than 18 months for treated populations. The treatment’s effective response rates further endorse its role in today’s oncology landscape.

Current Regulatory Status and Clinical Trials

Recently, cadonilimab received approval for use in advanced gastric cancer treatment, further broadening its therapeutic reach. The ongoing review for its use in cervical cancer treatment underscores Akeso's commitment to pushing the envelope in cancer care. With multiple trials underway across various cancers, cadonilimab is well-positioned to solidify its reputation in the competitive biopharmaceutical arena.

The Efficacy of Ivonescimab

Ivonescimab stands out as the first-of-its-kind antibody that combines cancer immunotherapy with anti-angiogenesis. In clinical trials, it demonstrated a remarkable capability to enhance patient outcomes, particularly in advanced stages of specific lung cancers. The encouraging results from the HARMONi trial series reveal its potential to drastically decrease the likelihood of disease progression.

Future Prospects for Ivonescimab

As further studies progress, including a pivotal review of ivonescimab for first-line treatment in lung cancer patients, there is strong anticipation surrounding its formal adoption in treatment protocols. Its inclusion in several treatment guidelines supports its reputation within the oncology community.

About Akeso

Founded in 2012, Akeso is dedicated to reshaping the biopharmaceutical landscape through its pioneering research and innovative drug development. With a diverse portfolio of over 50 assets in clinical development, including multiple bispecific antibodies, Akeso aims to provide affordable and effective treatments across various disease areas. Their commitment to scientific innovation ensures that patients receive the best possible care.

Frequently Asked Questions

What are cadonilimab and ivonescimab?

They are bispecific antibody drugs developed by Akeso for treating specific types of cancer.

How will inclusion in the NRDL affect patients?

Patients will have greater access to these innovative treatments, reducing financial burdens associated with cancer care.

What types of cancer do these drugs target?

Cadonilimab targets cervical cancer, while ivonescimab is for lung cancer with specific mutations.

What is Akeso's mission?

Akeso aims to provide first-in-class biopharmaceutical innovations to enhance patient care and access to treatments.

What is the significance of the NRDL in China?

The NRDL influences which medications are reimbursed under China's healthcare system, impacting healthcare access for millions.

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