Abbisko's Irpagratinib Triumphs at ESMO 2024 with New Results

Abbisko Celebrates Success at ESMO 2024

Abbisko Therapeutics is delighted to share the news of being honored with the Best Poster Award at ESMO 2024. Their presentation focused on the critically important findings regarding the safety and efficacy of Irpagratinib (ABSK011) in the treatment of advanced hepatocellular carcinoma (aHCC), particularly among patients with FGF19 overexpression. This award is a testament to the significant progress and dedication of Abbisko in addressing unmet medical needs in cancer treatment.

Key Data on Irpagratinib Presented

Outstanding Findings from the Study

A standout aspect of the data derived from the ABSK-011-101 study is the promising results for Irpagratinib monotherapy. Specifically, this study demonstrates a well-tolerated safety profile alongside noteworthy anti-tumor activity. For patients who had previously undergone treatment with both immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs), the Objective Response Rate (ORR) was remarkably recorded at 44.8%, indicating that nearly half of these patients experienced significant tumor reduction. Additionally, the Disease Control Rate (DCR) reached 79.3%, showcasing the drug's effectiveness in providing a clinical benefit to a population with high unmet medical needs.

Comprehensive Patient Overview

As reflected in the latest data, 122 patients were enrolled in this clinical trial, with a significant proportion categorized under BCLC Stage C, which is an advanced stage of liver cancer. Appraising the treatment responses also highlighted that out of specific patient subsets treated with the 220mg BID dose, a relative 36.8% response rate was achieved among evaluable patients. Moreover, longer durations of response (mDoR) and median progression-free survival (mPFS) at 7.4 months and 5.5 months, respectively, contributed to the rationale advocating further development of Irpagratinib for patients fitting this treatment scenario.

Safety Profile and Tolerability of Irpagratinib

While the efficacy of Irpagratinib is paramount, understanding its safety profile is equally crucial. In the 300mg BID treatment cohort, only one dose-limiting toxicity was recorded, and the most prevalent treatment-related adverse effects included elevations in liver enzymes and gastrointestinal discomfort. Importantly, no reports of grade 5 adverse events conveyed the drug's favorable safety profile, affirming its potential as a suitable therapeutic option for patients enduring advanced liver cancer.

The Significance of HCC Research

Hepatocellular carcinoma is a severe malignancy, constituting 85% to 90% of primary liver cancers, known for its aggressive nature and poor prognosis. Existing therapies have not effectively prolonged survival rates for many patients. The innovative approach of targeting the FGF19/FGFR4 signaling pathway is being explored further with Irpagratinib. As a selective FGFR4 inhibitor, it is designed to address specific molecular abnormalities in tumors, paving the way for treatments tailored to the unique profiles of patients suffering from this form of cancer.

About Irpagratinib and Abbisko Therapeutics

Irpagratinib represents a forward leap in the therapeutic arsenal available against advanced solid tumors prevalent in hepatocellular carcinoma and other cancers where aberrations in the FGF19/FGFR4 pathway occur. Abbisko Therapeutics, established in 2016, remains committed to discovering and developing innovative cancer treatments for patients both in China and globally. With an extensive pipeline of drug candidates, Abbisko focuses on precision oncology and is poised to make significant impacts in the medical community and patient lives alike.

Frequently Asked Questions

What is the significance of the ESMO 2024 Best Poster Award?

The award highlights the clinical importance and innovation presented in the research, distinguishing it within the scientific community.

Who benefits from Irpagratinib treatment?

Patients with advanced hepatocellular carcinoma, particularly those who have strong overexpression of FGF19 and who are heavily pre-treated, benefit from this treatment.

What are the common side effects of Irpagratinib?

Common side effects include elevated liver enzymes, diarrhea, and other gastrointestinal disturbances, with a favorable overall safety profile reported.

Is Irpagratinib part of a larger clinical development plan?

Yes, Abbisko Therapeutics is pursuing late-stage development for Irpagratinib, aimed at expanding its use for additional patient populations.

How does Abbisko Therapeutics contribute to oncology?

Abbisko focuses on the discovery and development of targeted therapies to meet unmet medical needs, enhancing treatment outcomes for cancer patients worldwide.

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