Telix Expands Its Pipeline with Acquisition of ImaginAb Assets

Telix's Strategic Acquisition for Future Growth

Telix Pharmaceuticals Limited (ASX: TLX, Nasdaq: TLX) has made significant strides in its mission to develop innovative therapeutics and diagnostics by acquiring advanced technology and assets from ImaginAb, Inc., an antibody engineering company. This acquisition is poised to enhance Telix's existing capabilities and broaden its pipeline of drug candidates aimed at high-value therapeutic targets.

Enhancing Therapeutic Offerings

The asset purchase agreement includes a rich pipeline of next-generation therapeutic candidates that targets critical proteins such as DLL3 and integrin ?v?6, along with various other novel targets currently in the discovery stage. These cutting-edge drug candidates align seamlessly with Telix's existing therapeutics pipeline, opening new avenues to address unmet clinical needs in diverse therapy areas.

Utilizing innovative, engineered antibody formats, the acquired intellectual property is designed for precise cancer targeting. This advancement facilitates quick tumor uptake and efficient blood clearance. The technology has the potential to be dynamic in both imaging and treatment modalities, especially when combined with a range of radioisotopes.

State-of-the-Art Research Facility

A major component of the transaction involves a state-of-the-art research facility that boasts a talented team specializing in protein engineering and radiopharmaceutical development. With these resources, Telix enhances its in-house capabilities for antibody engineering and preclinical development. This strategy will foster the creation of next-generation precision medicine products, extending beyond the current clinical-stage offerings.

Leadership Perspectives on the Acquisition

Richard Valeix, Chief Executive Officer of Therapeutics at Telix, emphasized the transformative potential of this acquisition: "By combining our proprietary drug discovery platform with ImaginAb's promising theranostic assets and subject matter expertise, we can significantly bolster our research and innovation capabilities now and in the future. This move allows us to delve into new disease categories utilizing cutting-edge radiotherapeutic technologies."

Commenting on the collaboration, Dr. Anna M. Wu, Co-Founder and Board Member of ImaginAb, stated, "As the radiopharmaceutical industry develops at a rapid pace, the demand for highly selective targeting agents is crucial to reduce off-target radiation. With Telix's partnership, we can unlock the full therapeutic capacity of our innovative platform technology."

Transaction Details

The asset purchase agreement includes a comprehensive technology license agreement that will complement the acquisition. The transaction is valued at US$45 million (AU$73 million), encompassing US$10 million in cash and US$31 million in equity at closing. Additionally, a deferred payment of up to US$4 million in equity is contingent on a 15-month indemnity period.

Telix anticipates that this acquisition could result in a total payment of up to US$185 million (AU$299 million) contingent on achieving predefined development and commercial milestones, with the possibility of cash or equity payments at its discretion. Moreover, royalties will apply to net sales in the low single digits post the development of the first four products, along with potential sublicense fees.

Completion of the Acquisition

Ordinary shares will be issued to ImaginAb under Telix's Listing Rule 7.1 placement capacity as part of the acquisition consideration. The equity consideration will be subject to voluntary escrow restrictions, with scheduled releases at 60, 90, and 120 days post-closing. The transaction's completion relies on customary conditions such as regulatory approvals.

About ImaginAb, Inc.

ImaginAb stands as a clinical-stage, revenue-generating biotechnology company focused on pioneering the next generation of radiopharmaceutical and imaging products. Known for its patented products that utilize engineered antibodies, ImaginAb maintains the specificity of conventional antibodies while ensuring biological inertness within the body.

Post-closure of the transaction with Telix, ImaginAb will focus on its lead imaging candidate, CD8 ImmunoPET, currently in Phase 2 clinical trials. This candidate is actively licensed for use in various oncology-related immunotherapy clinical trials, showcasing the potential for significant impact within the sector.

About Telix Pharmaceuticals Limited

Telix Pharmaceuticals focuses on the advancement and commercialization of therapeutic and diagnostic radiopharmaceuticals recognized for their role in addressing significant unmet medical needs. The company has established a global presence with operations extending beyond Australia to include the United States, Canada, Europe, and Japan.

Telix's flagship imaging product, gallium-68 (68Ga) gozetotide injection, has garnered approvals from multiple regulatory bodies, including the U.S. Food and Drug Administration (FDA), Australian Therapeutic Goods Administration (TGA), and Health Canada. With a robust pipeline of clinical and commercially viable products, Telix is committed to making a difference in oncology and rare disease treatment.

Frequently Asked Questions

What is the significance of Telix's acquisition of ImaginAb?

This acquisition enhances Telix's pipeline with next-generation therapeutic candidates and innovative biologics technology, allowing for expanded research and development capabilities in precision medicine.

How does the technology from ImaginAb benefit Telix?

The technology focuses on highly specific cancer targeting and rapid imaging capabilities, potentially increasing the effectiveness of treatments and offers broad application with various radioisotopes.

What are the financial details of the acquisition?

The acquisition is valued at US$45 million, structured with an upfront cash component and equity payments, along with possible future payments based on development milestones up to US$185 million.

What will ImaginAb focus on after this transaction?

ImaginAb will concentrate on advancing its CD8 ImmunoPET imaging candidate, which is currently in clinical trials, to benefit oncology treatments.

Where is Telix Pharmaceuticals headquartered?

Telix is headquartered in Melbourne, Australia, and has a strong presence in various international markets, emphasizing their dedication to global health solutions.

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