Innovative Advances in Organ-on-a-Chip Systems
World Precision Instruments (WPI) has teamed up with SynVivo Inc. to introduce a groundbreaking multiplexed TEER-on-a-Chip platform. This advanced solution is designed to transform how researchers monitor organ-on-a-chip systems by providing real-time data on cell barrier integrity. The new platform allows scientists to measure transepithelial electrical resistance (TEER) directly within microfluidic chips, paving the way for significant advancements in drug development and disease research.
Features of the TEER-on-a-Chip Platform
This revolutionary platform combines WPI's renowned EVOM™ measurement technology with SynVivo's innovative SynTEER™ models, which incorporate embedded electrodes. This integration offers researchers a powerful tool that streamlines the process of conducting TEER measurements across multiple channels simultaneously. By utilizing the EVOM-Chip™ system, researchers can perform continuous monitoring of barrier properties, which is crucial for understanding cell behavior in physiological conditions.
Real-time Monitoring for Enhanced Research
The ability to carry out real-time TEER measurements is a game changer for scientists. The synchronization of the EVOM-Chip™ technology with live-cell imaging means researchers can observe and record valuable data without disrupting the cells. As drug treatments are administered, researchers can monitor changes in barrier function dynamically, which is vital for accurate interpretation and reproducibility of experimental results.
Expert Insights on Collaborative Advances
Gwen Fewell, the President & CEO of SynVivo Inc., emphasized the significance of this collaboration, stating, "Integrating TEER measurement directly into our chip enhances data fidelity and reduces variability, key to enabling more predictive, standardized, and scalable in vitro models." This statement underscores the commitment of both organizations to deliver a robust solution for tackling complex challenges in central nervous system drug development and related research fields.
The Importance of TEER Measurements
Over the past 30 years, WPI's EVOM™ instrumentation has been the gold standard for assessing barrier function in biological systems. The partnership with SynVivo builds upon this legacy by enhancing the precision of TEER readings through its specifically designed OOC models. These improvements address critical gaps in the Organ-on-Chip (OOC) market, particularly around standardization and automation, facilitating wider adoption in pharmaceutical research.
Overcoming Challenges in OOC Research
Mark Rutledge, CEO of WPI, remarked on the existing challenges faced by the OOC community, highlighting the need for effective, non-destructive sensing methods like TEER measurements. The EVOM™ Chip addresses this critical need, enabling researchers to obtain reliable data throughout various stages of experimentation— from the initial cell seeding to post-drug evaluation. This ability significantly advances research in the fields of inflammation studies, neurovascular research, and CNS drug development.
First Demonstrations and Future Applications
The platform has initially been validated with SynVivo’s SynBBB™ Blood-Brain Barrier model. Early findings show a strong correlation between electrical resistance measurements and the functional properties of biological barriers, enhancing confidence in the technology's applications in testing and development scenarios.
Live Demonstrations at MPS World Summit
Research professionals can see the EVOM-Chip™ and SynTEER-on-a-Chip systems in action at the upcoming MPS World Summit. This event provides an excellent opportunity not just to observe the technology but also to understand how integrated TEER-on-Chip solutions can propel research forward by offering unprecedented insights into cell behavior and barrier dynamics.
- WPI Booth #131
- SynVivo Booth #404
Why Choose World Precision Instruments?
With over five decades of experience, World Precision Instruments stands out as a leader in providing cutting-edge research tools and equipment tailored for life sciences, healthcare, and industrial markets. Their commitment to innovation is evident in their dedication to support researchers in drug development, efficacy studies, and complex biological assessments.
Similarly, SynVivo is setting new standards in organ-on-chip technology by simulating human tissue microenvironments, essential for improving the accuracy of in vitro testing. This synergy of expertise is vital for developing future-proof solutions in the rapidly evolving landscape of biomedical research.
Frequently Asked Questions
What is the purpose of the TEER-on-a-Chip platform?
The TEER-on-a-Chip platform is designed for real-time monitoring of cell barrier integrity in organ-on-a-chip systems, significantly improving research capabilities.
How does the EVOM-Chip™ technology enhance research workflows?
The EVOM-Chip™ technology allows for simultaneous TEER measurements across multiple channels, streamlining data collection and improving reproducibility.
Where can I see the new technology demonstrated?
Live demonstrations of the technology will be available at the MPS World Summit, providing a hands-on experience for researchers.
What are the benefits of using OOC models in research?
Organ-on-chip models replicate human physiological conditions more accurately, leading to better predictive outcomes in drug discovery and disease research.
Who are the key players behind this advancement?
The collaboration between World Precision Instruments and SynVivo combines their expertise in TEER measurement and organ-on-chip technology to deliver innovative solutions for researchers.
