Thanks for sharing Jeff, great info! Kind of actually lines up with my prior dosing speculation that we needed to go 8-9 cohorts to see the really impressive results, as stated by the comapny as well. I think i was just high on my dosage estimates, it seems with the way dosing is escalating, if we go 8-9 cohorts with dealing with AE along the way, we may end up around 250-400mg/m2 MTD. Would you agree? seel?