I don't think the dosage has to be quite as high a

I don't think the dosage has to be quite as high as your 450 unit to be totally effective.  If it worked in animals in the 100-200 range, then 300 should be pretty good IMO.  Of course, 450 would be better but I can't see that as a bottom line necessity for full efficacy. 

Great post, showed a LOT of though put into it.