From Pharmaceuticalintelligence.com (as previously linked

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Sep 7, 2013 at 6:06 PM

From Pharmaceuticalintelligence.com (as previously linked to by that brainiac, the popo, over yonder and here, too, I do believe):

" Overall purpose is to find a method to manipulate IDO for clinical applications, mainly the focus of this review is is cancer prevention and treatment. The first study proving the connection between IDO and immune response came from, a very natural event, a protection of pregnancy in human. This led to discover that high IDO expression is a common factor in cancer tumors. Thus, attention promoted investigations on IDO’s role in various disease states, immune disorders, transplantation, inflammation, women health, mood disorders. Many approaches, vaccines and adjuvants are underway to find new immunotherapies by combining the power of DCs in immune response regulation and specific direction of siRNA . As a result, with this unique qualities of IDO, DCs and siRNA, we orchestrated a novel intervention for immunomodulation of IDO by inhibiting with small interference RNA, called siRNA-IDO-DCvax. Proven that our DCvax created a delay and regression of tumor growth without changing the natural structure and characterization of DCs in melanoma and breast cancers in vivo. (** The shRNA IDO- DCvax is developed by Regen BioPhrama, San Diego, CA , Thomas Ichim, Ph.D, CSO. and David Koos, CEO)"

Current IDO Clinical Trials; short version. Is a matter of time before Regen will be among these listed.

1	Clinical Trials From Clinicaltrials.Gov Title And Details Of The Study	NCT Number	Recruitment	Condition	Primary Completion Date	Sponsor/Collaborator	Phase or Observation.	Intervention Type
2	IDO Inhibitor Study For Relapsed Or Refractory Solid Tumors	NCT00739609	Terminated	Breast Cancer\|Lung Cancer\|Melanoma\|Pancreatic Cancer\|Solid Tumors	October 2012	NewlLink enetics Corp.	1	CHEM
3	IDO2 Genetic Status Informs The Neoadjuvant Efficacy Of Chloroquine (CQ) In Brain Metastasis Radiotherapy	NCT01727531	Recruiting	Brain Metastasis	Dec. 2020	Main Line Health	NA	CHEM
4	Peptide Vaccine And Temozolomide For Metastatic Melanoma Patients	NCT01543464	Recruiting	Malignant Melanoma	September 2014	Newlink Genetics Corporation	2	CHEM
5	A Phase 1/2 Randomized, Blinded, Placebo Controlled Study Of Ipilimumab In Combination With INCB024360 Or Placebo In Subjects With Unresectable Or Metastatic Melanoma	NCT01604889	Recruiting	Metastatic Melanoma	August 2014	Incyte Corporation	1/2	BIOL INH+ CHEM
6	A Phase 2 Study Of The IDO Inhibitor INCB024360 Versus Tamoxifen For Subjects With Biochemical-Recurrent-Only EOC, PPC Or FTC Following Complete Remission With First-Line Chemotherapy	NCT01685255	Recruiting		April 2014	Incyte Corporation	2	CHEM
7	Different Injection Number Of The Same Dose Of Botulinum Toxin A On Overactive Bladder Syndrome	NCT01657409	Recruiting	Overactive Bladder	March 2014	Buddhist Tzu Chi General Hospital	2	CHEM
8	Study On The Effect Of Intravenous Ascorbic Acid On Intraoperative Blood Loss In Women With Uterine Myoma Interventions: Drug: Ascorbic Acid	NCT01715597	Recruiting	Uterine Leiomyoma	January 2014	Seoul National University Hospital	3	CHEM
9	1-Methyl-D-Tryptophan In Treating Patients With Metastatic Or Refractory Solid Tumors That Cannot Be Removed By Surgery	NCT00567931	Recruiting	Unspecified Adult Solid Tumor, Protocol Specific	September 2013	National Cancer Institute (NCI)	1	CHEM
10	Properties Of Mesenchymal Stem Cells In Lung Transplant	NCT01668576	Recruiting	Lung Transplantation	August 2013	Emory University	OBS	BIOL
11	The Effects Of Medical Clowns In Children Undergoing Blood Tests	NCT01396876	Recruiting	Pain And Anxiety Reduction	July 2012	Tel-Aviv Sourasky Medical Center	NA	BIOL
12	Saline Injection - Assisted Anesthesia In Eyelid Surgery	NCT01239498	Recruiting	Blepharoptosis	October 2011	Sheba Medical Center	4	CHEM BIOL
13	Effects Of The Consumption Of California Walnuts On Cardiovascular Health Interventions: Dietary Supplement: Walnuts	NCT01235390	Recruiting	Cardiovascular Disease\|Immune Health	October 2011	University Of California, Davis\|California Walnut Commission	1	FOOD ALERGY-WALNUT
14	Pomegranate To Reduce Maternal And Fetal Oxidative Stress And Improve Outcome In Pregnancies Complicated With Preterm Premature Rupture Of The Membranes	NCT01584323	Recruiting	Preterm Premature Rupture Of Membranes\|Pregnant State	2013	Rambam Health Care Campus	NA	FOOD SUP
1	Phase II INCB024360 Study For Patients With Myelodysplastic Syndromes (MDS)	NCT01822691	Not Yet Recruiting	Myelodysplastic Syndromes	September 2015	H. Lee Moffitt Cancer Center And Research Institute\|Incyte Corporation	2	CHEM-BIOL?
2	Title: Schizophrenia Imaging	NCT01655472	Not Yet Recruiting	Foetal Differences Between Healthy And Schizophernic Parents	July 2014	Tel-Aviv Sourasky Medical Center	IMAGE N
3	C11 AMT Positron Emission Tomography (PET) Imaging In Patients With Metastatic Invasive Breast Cancer	NCT01302821	Not Yet Recruiting	Breast Cancer	April 2014	H. Lee Moffitt Cancer Center And Research Institute\|National Cancer Institute (NCI)	NA	BIOL DC AV-P53 MT RADIA
4	Sonographic Evaluation Of Visceral Fat After Bariatric Surgery	NCT01285791	Not Yet Recruiting	Morbid Obesity	April 2012	Hadassah Medical Organization	OBS	BIOL CELL
5	How Our Immune System Can Help Fight Cancer	NCT01042847	Not Yet Recruiting	Ovarian Cancer	January 2011	Winthrop University Hospita	EVAL NA	POLY. BIOL
6	Title: Study Of The Long-Term Effect Of Frequent Anti-VEGF Dosing On Retinal Function In Patients With Neovascular AMD	NCT00533689	Not Yet Recruiting	Electrophysiology	2013 NA	Tel-Aviv Sourasky Medical Center	NA EYE	BIOL
7	Microbial Surveillance In Children Hospitalized For Cardiovascular Surgery	NCT00426894	Not Yet Recruiting	Cardiac Surgery\|Perioperative Prophylaxis	2013 NA	Hadassah Medical Organization	OBS
8	Study Of Chemotherapy In Combination With IDO Inhibitor In Metastatic Breast Cancer	NCT01792050	Not Recruitinbut Active G	Metastatic Breast Cancer	January 2015	Newlink Genetics Corporation	2	CHEM
9	A Dose-Escalation Study In Subjects With Advanced Malignancies	NCT01195311	Not BUT Active Recruiting	Advanced Malignancies	November 2012	Incyte Corporation	1	CHEM DOSE
SP	Title: Mesalamine To Reduce T Cell Activation In HIV Infection	NCT01090102	Enrolling By Invitation	HIV Infections\|Sexually Transmitted Diseases\|Immune System Diseases\|Lentivirus Infections\|Acquired Immunodeficiency Syndrome	January 2013	UC, San Francisco\|California HIV/AIDS Research Program\|Salix Pharmaceuticals	4	CHEM
1	Study Of Indoleamine 2,3-Dioxygenase Activity, Serum Levels Of Cytokines, BDNF, BH4 And	NCT00919295	Completed	Fibromyalgia Syndrome	October 2011	Mahidol University\|University Of Texas\|University Of Wuerzburg	2	CHEM.
2	Diagnosis Of Posttraumatic Stress Disorder Following Primary Rhegmatogenous Retinal Detachment	NCT01233908	Completed	Stress Disorders, Post-Traumatic\|Retinal Detachment	September 2010	Sheba Medical Center	OBS EYE	BIOL
3	Comparison Of DCT, ORA And GAT In Eyes After Penetrating Keratoplasty	NCT00834782	Completed	Corneal Transplantation	December 2009	Sheba Medical Center	4
4	Disturbances Of Kynurenine Pathway Of Trytophan Metabolism In Schizophrenia: A Quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR) Study	NCT00573300	Completed	Schizophrenia	May 2009	North Suffolk Mental Health Association	OBSV.	BIOL
5	Effect Of Biological Therapy On Biomarkers In Patients With Untreated Hepatitis C, Metastatic Melanoma, Or Crohn Disease	NCT00897312	Completed	Melanoma	August 2008	Vanderbilt-Ingram Cancer Center\|National Cancer Institute (NCI)	OBSV.	BIOL-CHEM
6	A Prospective Comparative Study Of Induction Of Labor With A Cervical Ripening Double Balloon Vs Foley Catheter	NCT00501033	Completed	Induction Of Labor\|Cesarean\|Endometritis	February 2008	Western Galilee Hospital-Nahariya	NA	DEVICE
7	Tryptophan, Serotonin And Kynurenine In Septic Shock	NCT00684736	Completed	Shock, Septic	April 2007	Central Hospital, Versailles	OBS	KYN
8	Imatinib Mesylate In Treating Patients With Metastatic Breast Cancer	NCT00045188	Completed	Male Breast Cancer\|Recurrent Breast Cancer\|Stage IV Breast Cancer	July 2004	National Cancer Institute (NCI)	2	CHEM
9	IDO Peptid Vaccination For Stage III-IV Non Small-Cell Lung Cancer Patients.	NCT01219348	Completed	NSCLC\|Lung Cancer	NA	IDO Peptide Vaccinantio	1
10	Indoleamine 2,3-Dioxygenase (IDO) Activity In Patients With Chronic Lymphocytic Leukemia (CLL)	NCT01397916	Completed	CLL	NA	Tampere University Hospital	NA
11	Tryptophan Metabolism In Kidney Disease	NCT00758537	Completed	Chronic Kidney Disease	NA	Charite University, Berlin, Germany	OBS	BIOL TRP LEVELS
12	Observational To Investigate The Efficacy Of CRESTOR 5mg In Reaching LDL-C Target Goals In Patients Who Are At High Risk For A Cardiovascular Event	NCT00347217	Completed	Hypercholesteremia Cardiovascular	NA	Astrazeneca	4	CHEM
13	The Association Between Delivery Method And Maternal Rehospitalization	NCT00501501	Completed	Hospitalization	NA	Western Galilee Hospital-Nahariya	OBS	BIOL
14	Uterine Flora During Elective And Urgent Cesarean Sections	NCT00500019	Completed	Endometritis	NA	Western Galilee Hospital-Nahariya	OBS	BIOL
15	Title: Pilot, Proof-Of-Concept Study Of Sublingual Tizanidine In Children With Chronic Traumatic Brain Injury (TBI)	NCT00287157	Completed	Traumatic Brain Injury	NA	Teva GTC	1 B	CHEM

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