I think his comment about how they're not a company "rolling the dice on getting FDA approval on some therapy that may take 10 years to develop" is sort of ironic. They have progressed into a company that is doing just that. I would think that in order for Koos to decide to go the FDA route with the company that he would have had to see something that made him CERTAIN that he would be rewarded greatly. He clearly isn't some gambler who is wildly buying patents and hiring random researchers to develop therapies. SOMETHING he saw along the way changed his mind.