NBS Investment Highlights Divested ownership int
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[b]NBS >>> Investment Highlights[/b]
Divested ownership interest in Suzhou Erye Pharmaceutical Co, increasing its cash position by $12,280,000 - Already received $1,228,000 (10%)
Acute Myocardial Infarction (AMI) therapeutic product development team enrolled the first patient in the PreSERVE Phase 2 clinical trial
Our Progenitor Cell Therapy (PCT) CDMO service business continues to grow and has added new clients in later stage clinical trials setting the stage for expansion into larger and substantially more lucrative commercial manufacturing contracts
Jonathan Sackner-Bernstein, MD, FACC joined the Company. He was Associate Center Director for Technology and Innovation at the U.S. Food and Drug Administration's Center for Devices and Radiological Health
Actively pursuing additional strategic relationships with major pharmaceutical and biotechnology companies in 2012
WBB Securities LLC - UPGRADED TO STRONG BUY - $2.00 12 MONTH TARGET
Symbol is NBS
News Link: http://finance.yahoo.com/q?s=nbs&ql=1
NeoStem Fact Sheet Quick Recap - see below or Full FactSheet PDF link here
June 22, 2012
Fast Facts
Name: NeoStem, Inc.
Industry: Biotech / Cell Therapy
Ticker (Exchange): NBS (NYSE MKT)
All figures as of 6/18/12 except where noted
Stock Price: $0.47
52 Week Range: $0.30 – 1.76
Market Cap: $62.99 million
Average Volume (3 mos): 1,079,033
Shares Outstanding: 129.9 million*
*As of March 31, 2012
NeoStem Subsidiaries
Established Leader in Cell Therapy Services
150 years of combined management expertise in manufacturing, regulatory and commercialization for therapeutics development
$8-10 million in annual historic revenues
Manufactured 30,000+ cell therapy product procedures and delivered 6,000+ cell therapies to patients worldwide for more than 100 clients
50,000 square feet of cGMP manufacturing capability located in North America (East Coast and West Coast)
Large scale manufacturing for clients allows lower costs for internal cell therapy development
• Establish early partnering relationships with goals of commercial manufacturing, equity participation and back-end royalties
Emerging Leader in Cardiovascular Cell Therapy
Lead product, AMR-001, an autologous adult stem cell therapy for the prevention of major adverse cardiac events following acute myocardial infarction (AMI)
Launched Phase 2 clinical trial in 1Q-2012, data readouts expected 2H-2013
Potential for multiple indications beyond STEMI (i.e., congestive heart failure, other related vascular insufficiencies)
PreSERVE AMI Trial Phase 2 Clinical Plan
Indication Post-AMI preservation of cardiac function
Number of Subjects, Sites 160 patients, 34+ sites
Primary Endpoint Increased cardiac perfusion
Amorcyte: Using The CD34+ Natural Repair Mechanism
The body attempts to rescue damaged tissue to prevent ventricular remodeling:
A distress signal (HIF) is induced by hypoxia in the peri- infarct zone
HIF induces syntheses of SDF and VEGF, which mobilize CD34+CXCR4+ cells
The mobilized cells are trophic to the peri-infract zone, preventing apoptosis and effecting neoangiogenesis
AMR-001 is a homogeneous and highly purified cell population enriched for CD34+CXCR4+ cells
In Partnership with Becton Dickinson (20% Owner)
Immunotherapy Platform
• Immune mediated diseases are a result of imbalance between T effector cells and T regulatory cells
• T-reg therapy represents a novel approach for restoring immune balance by enhancing T-reg cell number/function
Opportunities in Regenerative Medicine
Cellular Differentiation with an Eye Toward Macular Degeneration
• Very small embryonic-like stem cells, shown to have several characteristics generally found in embryonic stem cells
• Activities have received awards of > $2.5 million to support this work
Upcoming Milestones
• Advance VSELs into a Phase Ia safety trial for macular degeneration (2013)
• PCT – Secure additional client contracts, establish client partnerships for commercial manufacturing and/or royalties, and expand manufacturing outside the U.S. (2012)
• Closing of divestiture of Suzhou Erye (51% NeoStem owned generic pharmaceutical company) (2012)
• Start Phase I trial in CHF with AMR-001 (2012/2013)
• Complete enrollment of Phase II trial (1H-2013)
• Data readouts for Phase II AMR-001 Trial (2H-2013)
• Athelos - data readout from work under independent physician INDs (1H-2013)
• Secure additional SBIR and/or DoD government grants for VSEL Technology (2012)
Contacts
Collaborations
Dr. Robin L. Smith
Chairman and Chief Executive Officer
212.584.4174
rsmith@neostem.com
Gitanjali Jain Ogawa
Trout Group - Vice President
646.378.2949
gogawa@troutgroup.com
This material contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements reflect management’s current expectations, as of the date hereof, and involve certain risks and uncertainties. Forward-looking statements include statements herein with respect to the successful execution of the Company’s business strategy, including with respect to the development of AMR-001 and other cell therapeutics, the future of the cell therapeutics industry, and the Company’s divestiture of its interest in Suzhou Erye Pharmaceutical Co., Ltd. The Company’s actual results could differ materially from those anticipated in these forward- looking statements as a result of various factors including those described under the heading "Risk Factors" in the Company’s filings with the Securities and Exchange Commission (www.sec.gov). The Company’s further development is highly dependent on future medical and research developments and market acceptance, which is outside its control.
NeoStem, Inc. (NYSE MKT: NBS)
420 Lexington Avenue, Suite 450
New York, NY 10170
212.584.4180
www.neostem.com
NeoStem, Inc.
420 Lexington Avenue
Suite 450
New York, New York 10170
Telephone: 212-584-4180
Fax: 646-514-7787
Website: www.neostem.com
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