Top Institutional HoldersHolder | Shares | % Out | Value* | Reported |
RA Capital Management, LLC |
7,327,092 |
9.30 |
34,070,977 |
Dec 31, 2012 |
Visium Asset Management |
4,681,603 |
5.94 |
21,769,453 |
Dec 31, 2012 |
Jay, Jeffrey R. |
2,351,477 |
2.99 |
10,934,368 |
Dec 31, 2012 |
BVF Inc. |
1,805,870 |
2.29 |
8,397,295 |
Dec 31, 2012 |
Vanguard Group, Inc. (The) |
1,621,584 |
2.06 |
7,540,365 |
Dec 31, 2012 |
Baker Brothers Advisors, LLC |
15,621,812 |
19.84 |
72,641,425 |
Dec 31, 2012 |
FMR LLC |
9,652,910 |
12.26 |
44,886,031 |
Dec 31, 2012 |
BlackRock Institutional Trust Company, N.A. |
1,170,943 |
1.49 |
5,444,884 |
Dec 31, 2012 |
Orbimed Advisors LLC. |
1,128,000 |
1.43 |
5,245,200 |
Dec 31, 2012 |
BlackRock Advisors, LLC |
1,112,118 |
1.41 |
5,171,348 |
Dec 31, 2012 |
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