thinking about our clover kras 350mg patient some more. who

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twinter11 smokeandmist #163954
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thinking about our clover kras 350mg patient some more. who was on 4th line including hai pump. Forst city of hope patient erolled. 1st week hit 70 percent ctdna reduction eventually progessing to 97 percent ctdna drop at 8 weeks. Still alive at 7 months..not sure how everything works right after leron gets administered.
maybe stroma effects. tcell invasion some.

 they had initial 21 percent reaching at some point 24 percent tumor shrinkage (kasi, conf call) . this patient was obviously immune compromised .
we don't know how much intial tcell health drives early infiltration of the tumor before pdl1 tcell evasion kicks in. but maybe less treated patients can drive enough early response before pdl1 upreg perhaps slows response, and kick it over the 30 percent line.

 I also read that tumor necrosis/dead tissue is many times converted into stroma using the same ccr5 axis that initially constructs the stroma.so maybe blocking ccr5 prevents that and alliws necrotic tissue to be cleared improving the shrinkage metric. so perhaps we can reach that 30 percent shrinkage in a lot of patients. 700mg may drive quicker tcell invasion.  Who knows

 I dont know it but I wonder if Doc J makes a panic move and forces ici earlier in the trial if he see futility.
I'm not worried.
I think we got it
And then the fda conversation switches to this upreg thing and what it portends.  And maybe some mythical rollover data.

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