ctDNA clearance is a pretty good thing. pretty good thing at 350mg dose. at 2 weeks none the less. with pretty good safe drug leronlimab. thanks to MGK i learned this today. i should be paying more attention but MGK does provide us will a wealth of detail that we often miss. the FACT that there is a cluster effect of occupancy, that its not a 1 to 1 ratio of molecule to receptor, but a cascade of one leronlimab molecule to multiple receptors collapsing on themselves. ( which we can assume is the foundation for a long acting leronlimab to somehow continue the collapsing effect for a single molecule of lernlimab? )
but back to ctDNA clearance. the fact that this acceptable and reliable test for ctDNA clearance is a blood test, and not an intrusive biopsy, means the science can move way faster and safer than ever before.
is ctDNA clearance a measurement of how well chemo is working? seems so.
https://oncodaily.com/oncolibrary/ctdna-clear...after-icis
will the medical establishment accept that ctDNA clearance is a measurement of how well leronlimab is working? they should...................................................................goose/gander
shouldnt leronlimab be approved for this function alone? there a chemo executive choking on a golf course somewhere today. his game is up. and he knows it.
Quote:This is why the 350mg dose is working better than traditional receptor occupancy mathematics would predict. The standard calculation assumes each leronlimab molecule blocks exactly one CCR5 receptor on the cell surface. The clustering and internalization mechanism means each leronlimab binding event triggers a cascade that removes multiple receptors simultaneously from the CAML and CTC surface. The functional receptor occupancy achieved at 350mg is substantially higher than the dose-to-receptor ratio calculation suggests, because the drug is not merely occupying individual receptors. It is triggering a cellular reorganization that physically removes receptor clusters from the surface entirely.
Source: https://investorshangout.com/post/view?id=6834626
but back to ctDNA clearance. the fact that this acceptable and reliable test for ctDNA clearance is a blood test, and not an intrusive biopsy, means the science can move way faster and safer than ever before.
is ctDNA clearance a measurement of how well chemo is working? seems so.
https://oncodaily.com/oncolibrary/ctdna-clear...after-icis
will the medical establishment accept that ctDNA clearance is a measurement of how well leronlimab is working? they should...................................................................goose/gander
shouldnt leronlimab be approved for this function alone? there a chemo executive choking on a golf course somewhere today. his game is up. and he knows it.
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