sherlock: Thanks for another interesting, provocative, and optimistic post. And as is customarily the case with your posts, notwithstanding that you were drilling down a bit on the medical data, I was again able to follow your train of thought without constantly having to reread sentences 2 or 3 times, a process imposed by my position in the dunce section of the science class that we conduct everyday here at the board. But I digress.
I do have one question though. When you say:
are you positing that all 4 disease control responders from the basket trial were receiving the FOLFOX chemo combo with LL and that none received TAS-102? If so, that would bode well for the high ORR results you predict for CLOVER (which I embrace). But Gemini is telling me that the 4 patients were using their physicians' choice for the chemo combo, which could have been FOLFOX, TAS, or even something else, there being no clear record of which chemo combo was utilized by the respective patients.
I know that my question is small potatoes in the scheme of things, but if the TAS/Avastin combo is really far more synergistic combined with LL than FOLFOX, (as DR Jay apparently believes) and none of the basket 4 received TAS/Avastin, I would feel even more confident on the looming CLOVER ORR front.
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I do have one question though. When you say:
Quote:... leronlimab clearly makes TAS-102 work better, synergistically, and leads to much more ctDNA declines than happened in the basket trial....
are you positing that all 4 disease control responders from the basket trial were receiving the FOLFOX chemo combo with LL and that none received TAS-102? If so, that would bode well for the high ORR results you predict for CLOVER (which I embrace). But Gemini is telling me that the 4 patients were using their physicians' choice for the chemo combo, which could have been FOLFOX, TAS, or even something else, there being no clear record of which chemo combo was utilized by the respective patients.
I know that my question is small potatoes in the scheme of things, but if the TAS/Avastin combo is really far more synergistic combined with LL than FOLFOX, (as DR Jay apparently believes) and none of the basket 4 received TAS/Avastin, I would feel even more confident on the looming CLOVER ORR front.
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