Quote:The architecture was always there. What has changed is the resolution at which it is now visible and the independence of the laboratories who confirm it. Six months ago the thesis was very compelling. Today it is documented at single-cell resolution, proven causal through Mendelian Randomization, confirmed at the phosphoprotein level...
And this presently-confirmed architecture remains the combination of three activities: anti-metastatic, anti-fibrotic, and PD-L1 upregulation. Is this correct? Or is there also an activity that destroys the tumor itself and not just priming it for the ICI class of drugs?
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Le-Ron-Li-Mab, and they have not.