Maybe someone here knows something about thus study and the implications for blocking ccr5 .Let me know
But it looks like this is just a preprint or whatever its called.
Frontiers | Quantitative phosphoproteomic profiling of CCL5/CCR5 signaling cascade in melanoma cells
https://share.google/IyykgVYnIJVdX6L3S
"Background: The CCL5/CCR5 axis plays a pivotal role in tumor progression and metastasis. We previously reported CCR5 promoted melanoma EMT and metastasis by upregulating TGFβ1 expression via the PI3K/AKT/GSK3β pathway. However, the full spectrum of downstream events triggered by CCR5 activation remains poorly understood.
.. "Notably, upon CCL5 stimulation, three cell cycle-associated proteins-CEP131, KHDRBS1, and MAPK6-underwent phosphorylation activation, but this activation was remarkably prevented by CCR5 knockout. Overall. these findings provide a comprehensive phosphorylation resource for dissecting the molecular mechanisms underlying CCL5/CCR5-facilitated tumor progression and identifying potential therapeutic targets."
Somebody find me a solid tumor type.
Or something in alz or als or ms or auto immune or stroke or something where they predict blocking ccr5 wont do anything.
And well give it a deep look.
Ive been trying to find one but nothing so far.
But it looks like this is just a preprint or whatever its called.
Frontiers | Quantitative phosphoproteomic profiling of CCL5/CCR5 signaling cascade in melanoma cells
https://share.google/IyykgVYnIJVdX6L3S
"Background: The CCL5/CCR5 axis plays a pivotal role in tumor progression and metastasis. We previously reported CCR5 promoted melanoma EMT and metastasis by upregulating TGFβ1 expression via the PI3K/AKT/GSK3β pathway. However, the full spectrum of downstream events triggered by CCR5 activation remains poorly understood.
.. "Notably, upon CCL5 stimulation, three cell cycle-associated proteins-CEP131, KHDRBS1, and MAPK6-underwent phosphorylation activation, but this activation was remarkably prevented by CCR5 knockout. Overall. these findings provide a comprehensive phosphorylation resource for dissecting the molecular mechanisms underlying CCL5/CCR5-facilitated tumor progression and identifying potential therapeutic targets."
Somebody find me a solid tumor type.
Or something in alz or als or ms or auto immune or stroke or something where they predict blocking ccr5 wont do anything.
And well give it a deep look.
Ive been trying to find one but nothing so far.
5
