Quote:increased PD-L1 isn't part of the cold to hot definition. its one mechanism for turning cold to hot.
and ccr5 inhibition isnt the only way to induce increased PD-L1 to prime a cold tumor for ICIs.
I think this one is FUD. You've ignored any idea that PD-L1 expression could be worth anything to an interested BP, and now you are running it down in other ways here too. But increasing PD-L1 in cold tumors will be valued very highly by pharma companies, and this can have a drastic effect on share price, because everyone knows its value.