Since Maraviroc was brought up by someone, it's important to be aware of the following regarding that drug:
"A black box warning is the FDA's most stringent safety notice for prescription drugs, appearing as a bolded, black-bordered box on, or in, the packaging to highlight severe, life-threatening, or permanently disabling risks. These warnings are mandated when clinical data demonstrates significant potential hazards."
Maraviroc (a.k.a. Selzentry) carries a major "black box" warning for hepatotoxicity (severe liver toxicity), which is the most serious type of warning issued by the FDA.
It is considered a major risk because it can lead to fatal or life-threatening liver problems, often preceded by allergic reactions, and is applied to a drug that must be used carefully in specific patient populations.
Key Aspects of the Maraviroc Black Box Warning:
Cardiovascular Risks: Clinical trials saw higher rates of heart attacks (myocardial infarction) in patients taking the drug compared to placebo. Increased risk of additional cardiovascular events, including myocardial ischemia, has been observed.
Hepatotoxicity: Liver failure and hepatitis have been reported.
Patients must monitor for symptoms like yellowing skin/eyes, dark urine, and upper right stomach pain. Other risks include infections, and postural hypotension.
Severe Skin/Allergic Reactions: Cases of severe rash, including Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported.
Toxic Epidermal Necrolysis (TEN) is a life-threatening skin disorder, often drug-induced, characterized by widespread blistering, skin death (necrosis), and detachment of the epidermis (>30% of body surface). It presents with fever, severe pain, and mucous membrane involvement, requiring immediate ICU or burn unit treatment, often due to sepsis, with a mortality rate of up to 50%.
Immune Reconstitution Syndrome: The immune system may trigger dormant infections or autoimmune disorders.
Infection Risk: Potential for increased risk of serious infections.
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CYDY's Leronlimab, on the other hand, has shown a favorable safety profile across trials for HIV, COVID-19, and cancer, and is well-tolerated with rare and mostly mild adverse events such as injection site reactions, fatigue and diarrhea.
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I remain... #BULLISH
#CYDY #CCR5 #LERONLIMAB #DRJAY #DRKASI #OPENWATERS #OPENLABEL #ctDNA #CRC #COLDTOHOT
#STOP_THE_FUD!
"A black box warning is the FDA's most stringent safety notice for prescription drugs, appearing as a bolded, black-bordered box on, or in, the packaging to highlight severe, life-threatening, or permanently disabling risks. These warnings are mandated when clinical data demonstrates significant potential hazards."
Maraviroc (a.k.a. Selzentry) carries a major "black box" warning for hepatotoxicity (severe liver toxicity), which is the most serious type of warning issued by the FDA.
It is considered a major risk because it can lead to fatal or life-threatening liver problems, often preceded by allergic reactions, and is applied to a drug that must be used carefully in specific patient populations.
Key Aspects of the Maraviroc Black Box Warning:
Cardiovascular Risks: Clinical trials saw higher rates of heart attacks (myocardial infarction) in patients taking the drug compared to placebo. Increased risk of additional cardiovascular events, including myocardial ischemia, has been observed.
Hepatotoxicity: Liver failure and hepatitis have been reported.
Patients must monitor for symptoms like yellowing skin/eyes, dark urine, and upper right stomach pain. Other risks include infections, and postural hypotension.
Severe Skin/Allergic Reactions: Cases of severe rash, including Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported.
Toxic Epidermal Necrolysis (TEN) is a life-threatening skin disorder, often drug-induced, characterized by widespread blistering, skin death (necrosis), and detachment of the epidermis (>30% of body surface). It presents with fever, severe pain, and mucous membrane involvement, requiring immediate ICU or burn unit treatment, often due to sepsis, with a mortality rate of up to 50%.
Immune Reconstitution Syndrome: The immune system may trigger dormant infections or autoimmune disorders.
Infection Risk: Potential for increased risk of serious infections.
_______________________________________________________________
CYDY's Leronlimab, on the other hand, has shown a favorable safety profile across trials for HIV, COVID-19, and cancer, and is well-tolerated with rare and mostly mild adverse events such as injection site reactions, fatigue and diarrhea.
________________________________________________________________
I remain... #BULLISH
#CYDY #CCR5 #LERONLIMAB #DRJAY #DRKASI #OPENWATERS #OPENLABEL #ctDNA #CRC #COLDTOHOT
#STOP_THE_FUD!
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