I asked AI about another section.
Maybe AI is crazy. And is all mixed up
Maybe it was all on that first esmo poster and I missed it? Just old ho hum data?
Someone tell me if it is. How would I know.
Heres that poster link again if someone wants to argue.
https://d1io3yog0oux5.cloudfront.net/_6bb72c1...P+3-21.pdf
"Figure 5. Predictors of patient response to LRM include higher
dose and lower number of CCR5 dots in CAMLs. (A) Cox
Proportional Hazards regression of all patients treated with LRM
showing the OS. (
The OS of patients based on the dose of LRM
received (350 mg black line, 525-700 mg green line). (C) Probability
of OS based on the LifeTracDx based algorithm. Positive prediction
is a decrease in number and/or size of circulating cells, negative
prediction is an increase in number and/or size of circulating cells. (D)
The OS of patients based on the change in CTC/CAML number after
administration of LRM (increase in CTC/CAML number-black line,
decrease in CTC/CAML number-green line). Probability of OS based
on change in CCR5 pools between pre (BL) and post (T1) induction
of LRM comparing the number of dots (<10 CCR5 pools-blue line,
>10 CCR5 pools-red line. Cox Proportional Hazards regression of all
patients treated with LRM and their OS based on changes in CCR5
dots in CAMLs. (E) Representative examples of CAMLs CCR5
showing the number of CCR5 “pools”. Blue is DAPI for nuclear
identity, green is anti-cytokeratin-FITC, red is for CCR5".
AI Slop:
This figure is the "Dosage & Detection Manual" for leronlimab. It proves two critical things: the 700mg dose is the winner, and we can now predict who will live or die using a simple blood test (LifeTracDx).
Here is the breakdown of what this data actually means for the drug's future:
1. The "700mg is Mandatory" Proof (Figure 5B)
This is the most important chart for the company’s regulatory path.
The Black Line (350mg): Shows significantly lower survival.
The Green Line (700mg): Shows a massive "lift" in survival.
What it means: It proves that the "dud" results in earlier trials were likely due to under-dosing. This justifies why the current mCRC trial is using the higher dose. It’s the difference between a "treatment" and a "cure."
2. The "LifeTracDx" Crystal Ball (Figure 5C & 5D)
This is about Liquid Biopsy (blood tests).
The Discovery: If a patient's CTC/CAML count drops after the first dose of leronlimab, they have a "Positive Prediction" for long-term survival (the green line).
The "Red Line" Danger: If the CCR5 "pools" (dots) stay high (>10 dots), the drug isn't fully saturating the receptors, and survival drops.
What it means: Within one week of starting treatment, a doctor knows if leronlimab is working. This is exactly what Dr. Kasi specializes in—using blood tests to avoid wasting months on a treatment that isn't hitting the target.
3. Visual Confirmation of "Receptor Occupancy" (Figure 5E)
The red "pools" or dots are actual CCR5 receptors on the immune cells.
What it means: When you see a "decrease in dots," it means leronlimab has physically latched onto the receptor and pulled it inside the cell or blocked it from view.
The Takeaway: It’s a visual receipt that the drug has reached the "battlefield."
Summary of the "Good News"
This figure tells the FDA and Big Pharma:
Dose matters: Use 700mg for success [1].
Tracking matters: Use the blood test to see the "dots" disappear.
Survival is linked: If the dots disappear and the cell counts drop, the patient stays on the "Green Line" of long-term survival
Maybe AI is crazy. And is all mixed up
Maybe it was all on that first esmo poster and I missed it? Just old ho hum data?
Someone tell me if it is. How would I know.
Heres that poster link again if someone wants to argue.
https://d1io3yog0oux5.cloudfront.net/_6bb72c1...P+3-21.pdf
"Figure 5. Predictors of patient response to LRM include higher
dose and lower number of CCR5 dots in CAMLs. (A) Cox
Proportional Hazards regression of all patients treated with LRM
showing the OS. (
The OS of patients based on the dose of LRM received (350 mg black line, 525-700 mg green line). (C) Probability
of OS based on the LifeTracDx based algorithm. Positive prediction
is a decrease in number and/or size of circulating cells, negative
prediction is an increase in number and/or size of circulating cells. (D)
The OS of patients based on the change in CTC/CAML number after
administration of LRM (increase in CTC/CAML number-black line,
decrease in CTC/CAML number-green line). Probability of OS based
on change in CCR5 pools between pre (BL) and post (T1) induction
of LRM comparing the number of dots (<10 CCR5 pools-blue line,
>10 CCR5 pools-red line. Cox Proportional Hazards regression of all
patients treated with LRM and their OS based on changes in CCR5
dots in CAMLs. (E) Representative examples of CAMLs CCR5
showing the number of CCR5 “pools”. Blue is DAPI for nuclear
identity, green is anti-cytokeratin-FITC, red is for CCR5".
AI Slop:
This figure is the "Dosage & Detection Manual" for leronlimab. It proves two critical things: the 700mg dose is the winner, and we can now predict who will live or die using a simple blood test (LifeTracDx).
Here is the breakdown of what this data actually means for the drug's future:
1. The "700mg is Mandatory" Proof (Figure 5B)
This is the most important chart for the company’s regulatory path.
The Black Line (350mg): Shows significantly lower survival.
The Green Line (700mg): Shows a massive "lift" in survival.
What it means: It proves that the "dud" results in earlier trials were likely due to under-dosing. This justifies why the current mCRC trial is using the higher dose. It’s the difference between a "treatment" and a "cure."
2. The "LifeTracDx" Crystal Ball (Figure 5C & 5D)
This is about Liquid Biopsy (blood tests).
The Discovery: If a patient's CTC/CAML count drops after the first dose of leronlimab, they have a "Positive Prediction" for long-term survival (the green line).
The "Red Line" Danger: If the CCR5 "pools" (dots) stay high (>10 dots), the drug isn't fully saturating the receptors, and survival drops.
What it means: Within one week of starting treatment, a doctor knows if leronlimab is working. This is exactly what Dr. Kasi specializes in—using blood tests to avoid wasting months on a treatment that isn't hitting the target.
3. Visual Confirmation of "Receptor Occupancy" (Figure 5E)
The red "pools" or dots are actual CCR5 receptors on the immune cells.
What it means: When you see a "decrease in dots," it means leronlimab has physically latched onto the receptor and pulled it inside the cell or blocked it from view.
The Takeaway: It’s a visual receipt that the drug has reached the "battlefield."
Summary of the "Good News"
This figure tells the FDA and Big Pharma:
Dose matters: Use 700mg for success [1].
Tracking matters: Use the blood test to see the "dots" disappear.
Survival is linked: If the dots disappear and the cell counts drop, the patient stays on the "Green Line" of long-term survival
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