Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer
Too many ccr5 references.
https://www.nature.com/articles/s41392-026-02594-8
..."Pharmacological modulation of lipid-driven signaling pathways through CCR5 inhibition (inflammation modulation through xxmaravirocxx) or blockade of the lipid scavenger receptor CD36 reprograms TAMs, restores T cell activity, and enhances antitumor immune responses within lipid-rich tumor niches"".
..."In omental metastases, more lipids are associated to better tumor-infiltrating lymphocyte abundance and fitness along with oxidative distress in TAMs. In patient-derived tumor explants, xxMaravirocxx-mediated CCR5 inhibition or Fatty acid translocase (CD36) blockade reprograms TAMs, allowing the re-allocation of tumor infiltrating lymphocytes (TILs) towards the tumor core and supporting the anti-tumor immune response in omental metastases"...
..."However, the fiber distribution in the omentum metastases was not homogeneous, with more collagen fibers present at the tumor-omentum interface (supplementary Fig. 4c–e). In patient-derived explants, maraviroc treatment significantly decreased the proportion of the tissue surface occupied by collagen fibers (supplementary Fig. 4f). The observed decrease in fibrosis could also account for the T-cell migration and expansion triggered by maraviroc treatment"...
Too many ccr5 references.
https://www.nature.com/articles/s41392-026-02594-8
..."Pharmacological modulation of lipid-driven signaling pathways through CCR5 inhibition (inflammation modulation through xxmaravirocxx) or blockade of the lipid scavenger receptor CD36 reprograms TAMs, restores T cell activity, and enhances antitumor immune responses within lipid-rich tumor niches"".
..."In omental metastases, more lipids are associated to better tumor-infiltrating lymphocyte abundance and fitness along with oxidative distress in TAMs. In patient-derived tumor explants, xxMaravirocxx-mediated CCR5 inhibition or Fatty acid translocase (CD36) blockade reprograms TAMs, allowing the re-allocation of tumor infiltrating lymphocytes (TILs) towards the tumor core and supporting the anti-tumor immune response in omental metastases"...
..."However, the fiber distribution in the omentum metastases was not homogeneous, with more collagen fibers present at the tumor-omentum interface (supplementary Fig. 4c–e). In patient-derived explants, maraviroc treatment significantly decreased the proportion of the tissue surface occupied by collagen fibers (supplementary Fig. 4f). The observed decrease in fibrosis could also account for the T-cell migration and expansion triggered by maraviroc treatment"...
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