Q&A: HIV drug may be key to halting glioblastoma cell growth
..."In GBM, we found that CCR5 is highly expressed in patient tumors, and higher CCR5 levels are associated with poorer patient survival, suggesting an important role for CCR5 in GBM progression.
Consistent with this, we demonstrated that CCR5 is essential for maintaining glioma stem cells — a small but aggressive subpopulation of tumor cells with stem-like properties that drive tumor recurrence and resistance to therapy. At the cellular level, we showed that xxxx disrupts tumor cell growth and stemness. Studies to define the underlying molecular mechanisms are ongoing in our laboratory"...
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