“"First, an investigator at City of Hope has received
“"First, an investigator at City of Hope has received institutional approval for a study of subcutaneous leronlimab given in combination with a regimen of chemotherapy administered through the hepatic artery in treatment-naïve patients with mCRC who have metastatic disease confined to the liver. This study seeks to leverage CytoDyn’s previously announced data demonstrating leronlimab’s ability to mitigate liver toxicity in prior preclinical studies, as well as certain preliminary results from the phase II CRC study."
I suspect from “preliminary results” there was a patient that has demonstrated hepatic metastatic lesions and in the course of Leronlimab treatment either through CT or MRI these lesions showed measurable reduction in size and potential elimination. The observation was remarkable enough that it triggered a physician-sponsored dual therapy study involving highly targeted chemo through the hepatic artery in conjunction with Leronlimab. Liver Mets with CRC is quite common, often the first secondary site and affecting half of CRC patients so the oncologists have to grapple with it frequently. Thinks have changed but when I received my clinical training liver cancer at the time was a 3 month timeline from diagnosis to death. Seeing a patient respond while on Leronlimab was a lightbulb moment. I would not be surprised if this was fast-tracked through their IRB…the observation would have been of signal importance.
Respert is right, they are already seeing results in the CRC study and this is huge and very encouraging both to patients and the treating oncologist but also by extension to shareholders.
23
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