The most common and well known rare diseases are Ehlers Danlos Syndrome (EDS), sickle cell disease, cystic fibrosis, Duchenne Muscular Dystrophy (DMD), and haemophilia, which are only a few examples of the vast list of rare diseases.
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https://www.eds.clinic/articles/biomarkers-in...s-syndrome
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Most of the morbidity and mortality in CF patients result from pulmonary complications."
Chronic infection of the lungs with mucoid strains of Pseudomonas aeruginosa (PA), which tends to persist in most patients, results in an exaggerated neutrophilic inflammatory response and in a dysregulated production of cytokines such as high levels of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)] and low levels of anti-inflammatory IL-10 in bronchoalveolar lavage (BAL) fluids
*Reminds of our past Pulmonary trial mentions & Dr. J Rx video mentions "lung".
https://journals.physiology.org/doi/full/10.1...00206.2005
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Therefore, the aim of this article is to review the role of CCR5 and the effects of CCR5Δ32 on bacterial (brucellosis, osteomyelitis, pneumonia, tuberculosis and infection by Chlamydia trachomatis) and parasitic infections (toxoplasmosis, leishmaniasis, Chagas disease on schistosomiasis). Basic information about each of these infections was also addressed.
The neglected role of CCR5 in fungal disease and emerging studies regarding the action of CCR5 on regulatory T cells are briefly covered in this review.
https://onlinelibrary.wiley.com/doi/10.1111/iji.12485
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Maybe Max has been working on areas like these examples & others. Infectious & autoimmune pre-dates his Hiv days.
Will see if he jumps LL into Rare, via Orphan & then can grab all the funds, tax breaks & any of the other benefits for Rare Diseases
___
https://www.eds.clinic/articles/biomarkers-in...s-syndrome
___
Most of the morbidity and mortality in CF patients result from pulmonary complications."
Chronic infection of the lungs with mucoid strains of Pseudomonas aeruginosa (PA), which tends to persist in most patients, results in an exaggerated neutrophilic inflammatory response and in a dysregulated production of cytokines such as high levels of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)] and low levels of anti-inflammatory IL-10 in bronchoalveolar lavage (BAL) fluids
*Reminds of our past Pulmonary trial mentions & Dr. J Rx video mentions "lung".
https://journals.physiology.org/doi/full/10.1...00206.2005
___
Therefore, the aim of this article is to review the role of CCR5 and the effects of CCR5Δ32 on bacterial (brucellosis, osteomyelitis, pneumonia, tuberculosis and infection by Chlamydia trachomatis) and parasitic infections (toxoplasmosis, leishmaniasis, Chagas disease on schistosomiasis). Basic information about each of these infections was also addressed.
The neglected role of CCR5 in fungal disease and emerging studies regarding the action of CCR5 on regulatory T cells are briefly covered in this review.
https://onlinelibrary.wiley.com/doi/10.1111/iji.12485
___
Maybe Max has been working on areas like these examples & others. Infectious & autoimmune pre-dates his Hiv days.
Will see if he jumps LL into Rare, via Orphan & then can grab all the funds, tax breaks & any of the other benefits for Rare Diseases
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