"Although maraviroc exerts immunomodulatory effects in

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twinter11 misiu143 #158742
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"Although maraviroc exerts immunomodulatory effects in peripheral tissues, its constrained CNS penetration raises concerns regarding adequate engagement of CCR5 within spinal and supraspinal regions that mediate pain processing"

Sounds like trouble crossing BBB and also the old spinal and surpraspinal regions

And if given enough to penetrate and occupy, it damages the liver.

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