Feinstein Institutes for Medical Research Northw
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Posted On: 11/28/2025 1:05:15 PM
Feinstein Institutes for Medical Research
Northwest Health
Timir Datta-Chaudhuri, PhD
Assistant Professor, Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research
About the investigator
Timir Datta-Chaudhuri, PhD, received his BS, MS and PhD in electrical engineering from the University of Maryland. His thesis work was on the development of hybrid bioelectronic sensing systems, integrating complementary metal oxide semiconductor (CMOS) circuits with living systems. He was recruited into the Neural Technologies Group within the Center for Bioengineering at Lawrence Livermore National Laboratory as a postdoctoral fellow in 2015. His research focus was on the development of implantable neural interfaces for restoring memory and the treatment of neuropsychiatric disorders. His research interests include brain-machine interfaces, lab-on-a-chip, cell-based sensing, biosensors, microsystem design and packaging, mixed-signal integrated circuit design, adaptive analog circuits and neuromorphic engineering.
In 2017, Dr. Datta-Chaudhuri accepted a position as an assistant professor at the Feinstein Institutes for Medical Research, where he joined the Institute of Bioelectronic Medicine as the head of the bioelectronics and biosensing laboratory.
Research focus
Dr. Datta’s work has always focused on the intersection of biology and electronics. His early work involved neural networks and neuromorphic computing, building systems that emulated the computational capability of biology by employing spiking neural networks built using silicon integrated circuits. He then went on to develop lab-on-CMOS systems that intimately combined electronics and biology to create hybrid bioelectronics systems with capabilities greater than the sum of their parts.
These systems included electrical and optical interfaces to living cells as well as electronics that were designed to interact with living systems. The living cells were used to sense the environment and the signals from the cells were processed by the onboard electronics using the same computational paradigms seen in biology. Building these systems required developing novel die-level packaging techniques to allow the biology and electronics to work together harmoniously. Now his work focuses on the development on implantable neural interfaces for treatment of diseases and augmenting human capability.
Lab information
The underlying goal of the work performed at the Bioelectronics and Biosensing Laboratory is the development of next-generation bioelectronic therapeutic devices. Working with the other collaborating laboratories at the Center for Bioelectronic Medicine, the Bioelectronics and Biosensing Laboratory develops miniaturized implantable devices that will enable later-stage clinical trials and eventually the commercial realizations of the bioelectronics therapies being pioneered at the Feinstein Institutes for Medical Research. The work performed at the laboratory consists of developing the miniaturized electronics and implantable packages required for chronically implantable neural interfaces as well as answering the basic scientific questions about the optimal ways to apply bioelectronic therapies to maximize efficacy through selective targeting.
Implantable stimulators
The lab is developing the next generation of implantable neuromodulation devices for preclinical models. A new chronically implantable neruostimulator for small animals, which is less than 1.5cc, has been developed. The device can be used to stimulate the vagus nerve, other peripheral nerve targets, or the brain using electrical or optogenetic stimulation methods. This system enables the study of long-term effects of stimulation and the discovery of new therapies for bioelectronic medicine.
Closed-loop systems
Closing the loop in bioelectronic medicine allows both responsive and adaptive stimulation therapies tailored to an individual. The lab is developing a closed-loop implantable device for small animals that enables monitoring of the real-time and long-term neural and physiological effects of neuromodulation to inform the delivery of targeted stimulation paradigms. The system will be able to stimulate the vagus nerve or other peripheral and central nervous system targets while using wireless telemetry to allow real-time streaming of multiple channels of biopotential and physiological data. Future goals include integration of biosensing capabilities, allowing researchers to track the effects of stimulation-based therapies on biomolecules such as inflammatory markers in real-time.
Wireless power
Implantable devices need to be powered, and current battery technology does not meet the needs of next generation devices for preclinical models. The bioelectronics and biosensing laboratory is developing new techniques for wirelessly powering small implantable devices. The commercially available wireless powering technology, such as those used to recharge mobile phones, is too restrictive to allow freedom of movement. The lab is utilizing resonantly coupled magnetic fields to deliver power over a large volume, allowing experiments where free movement and behavior is permitted.
Implantable packaging
Biology is a wet world; electronics come from a dry world. The marriage of these two domains requires careful encapsulation to protect the body and keep the electronics functioning. Standard medical devices use packaging methods, including metal cans and ceramic feedthroughs, which are prohibitively expensive and have undesirably high mass for preclinical models. The laboratory has developed novel polymeric encapsulation and feedthrough technologies that are light enough to be implanted in small animals while still allowing the systems to function for time durations appropriate for the study of disease progression and treatment.
Noninvasive clinical trials
The lab is interested in noninvasive methods to electrically stimulate the vagus nerve. Noninvasive methods allow for quick clinical translation of new findings. The lab has developed a wireless over-the-ear device which is now being used to study the effects trans-auricular vagus nerve stimulation (TaVNS). Partnering with clinicians at Northwell Health, the lab is participating in a number of clinical trials looking at the effects of TaVNS.
Education
University of Maryland College Park, MD
Degree: BS
Field of study: Electrical engineering
2007
University of Maryland College Park, MD
Degree: MS
Field of study: Electrical engineering
2013
University of Maryland College Park, MD
Degree: PhD
Field of study: Electrical engineering
2015
Electrical engineering
2015
Honors & awards
2016 DARPA Program Leadership Award, Lawrence Livermore National Laboratory
2016 Engineering Directorate Award, Lawrence Livermore National Laboratory
2014 Circuits and Systems Society Travel Award, IEEE
2014 Student Travel Award, IEEE
2013 Graduate All-S.T.A.R. Fellow, University of Maryland
2012 School of Engineering Future Faculty Fellow, University of Maryland
2011 Qualcomm Innovation Fellowship Finalist
Publications
1. Transcutaneous auricular vagus nerve stimulation reduces pain and fatigue in patients with systemic lupus erythematosus: a randomised, double-blind, sham-controlled pilot trial, Aranow C., Atish-Fregoso Y, Lesser M, Mackay M, Anderson E, Chavan S, Zanos T, Datta-Chaudhuri T, Bouton C, Tracey K J, Diamond B, Annals of the Rheumatic Diseases, 2020.
2. Ultrasound powered piezoelectric neurostimulation devices: a commentary , Sun T, Wright J, Datta-Chaudhuri T, Bioelectronic Medicine, 2020.
3. Specific vagus nerve stimulation parameters alter serum cytokine levels in the absence of inflammation, Tsaava T, Datta-Chaudhuri T, Addorisio M E, Masi E B, Silverman H A, Newman J E, Imperato G H, Bouton C, Tracey K J, Chavan S S, Chang E H, Bioelectronic Medicine, 2020.
4. Quantitative estimation of nerve fiber engagement by vagus nerve stimulation using physiological markers , Chang YC, Cracchiolo M, Ahmed U, Mughrabi I, Gabalski A, Daytz A, Rieth L, Becker L, Datta-Chaudhuri T, Al-Abed Y, Zanos T, Zanos S, Brain Stimulation, 2020.
5. Anodal block permits directional vagus nerve stimulation , Ahmed U, Chang YC, Cracchiolo M, Lopez M, Tomaio J, Datta-Chaudhuri T, Zanos T, Rieth L, Al-Abed Y, Zanos S, Scientific Reports, 2020.
https://feinstein.northwell.edu/institutes-re...udhuri-phd
Northwest Health
Timir Datta-Chaudhuri, PhD
Assistant Professor, Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research
About the investigator
Timir Datta-Chaudhuri, PhD, received his BS, MS and PhD in electrical engineering from the University of Maryland. His thesis work was on the development of hybrid bioelectronic sensing systems, integrating complementary metal oxide semiconductor (CMOS) circuits with living systems. He was recruited into the Neural Technologies Group within the Center for Bioengineering at Lawrence Livermore National Laboratory as a postdoctoral fellow in 2015. His research focus was on the development of implantable neural interfaces for restoring memory and the treatment of neuropsychiatric disorders. His research interests include brain-machine interfaces, lab-on-a-chip, cell-based sensing, biosensors, microsystem design and packaging, mixed-signal integrated circuit design, adaptive analog circuits and neuromorphic engineering.
In 2017, Dr. Datta-Chaudhuri accepted a position as an assistant professor at the Feinstein Institutes for Medical Research, where he joined the Institute of Bioelectronic Medicine as the head of the bioelectronics and biosensing laboratory.
Research focus
Dr. Datta’s work has always focused on the intersection of biology and electronics. His early work involved neural networks and neuromorphic computing, building systems that emulated the computational capability of biology by employing spiking neural networks built using silicon integrated circuits. He then went on to develop lab-on-CMOS systems that intimately combined electronics and biology to create hybrid bioelectronics systems with capabilities greater than the sum of their parts.
These systems included electrical and optical interfaces to living cells as well as electronics that were designed to interact with living systems. The living cells were used to sense the environment and the signals from the cells were processed by the onboard electronics using the same computational paradigms seen in biology. Building these systems required developing novel die-level packaging techniques to allow the biology and electronics to work together harmoniously. Now his work focuses on the development on implantable neural interfaces for treatment of diseases and augmenting human capability.
Lab information
The underlying goal of the work performed at the Bioelectronics and Biosensing Laboratory is the development of next-generation bioelectronic therapeutic devices. Working with the other collaborating laboratories at the Center for Bioelectronic Medicine, the Bioelectronics and Biosensing Laboratory develops miniaturized implantable devices that will enable later-stage clinical trials and eventually the commercial realizations of the bioelectronics therapies being pioneered at the Feinstein Institutes for Medical Research. The work performed at the laboratory consists of developing the miniaturized electronics and implantable packages required for chronically implantable neural interfaces as well as answering the basic scientific questions about the optimal ways to apply bioelectronic therapies to maximize efficacy through selective targeting.
Implantable stimulators
The lab is developing the next generation of implantable neuromodulation devices for preclinical models. A new chronically implantable neruostimulator for small animals, which is less than 1.5cc, has been developed. The device can be used to stimulate the vagus nerve, other peripheral nerve targets, or the brain using electrical or optogenetic stimulation methods. This system enables the study of long-term effects of stimulation and the discovery of new therapies for bioelectronic medicine.
Closed-loop systems
Closing the loop in bioelectronic medicine allows both responsive and adaptive stimulation therapies tailored to an individual. The lab is developing a closed-loop implantable device for small animals that enables monitoring of the real-time and long-term neural and physiological effects of neuromodulation to inform the delivery of targeted stimulation paradigms. The system will be able to stimulate the vagus nerve or other peripheral and central nervous system targets while using wireless telemetry to allow real-time streaming of multiple channels of biopotential and physiological data. Future goals include integration of biosensing capabilities, allowing researchers to track the effects of stimulation-based therapies on biomolecules such as inflammatory markers in real-time.
Wireless power
Implantable devices need to be powered, and current battery technology does not meet the needs of next generation devices for preclinical models. The bioelectronics and biosensing laboratory is developing new techniques for wirelessly powering small implantable devices. The commercially available wireless powering technology, such as those used to recharge mobile phones, is too restrictive to allow freedom of movement. The lab is utilizing resonantly coupled magnetic fields to deliver power over a large volume, allowing experiments where free movement and behavior is permitted.
Implantable packaging
Biology is a wet world; electronics come from a dry world. The marriage of these two domains requires careful encapsulation to protect the body and keep the electronics functioning. Standard medical devices use packaging methods, including metal cans and ceramic feedthroughs, which are prohibitively expensive and have undesirably high mass for preclinical models. The laboratory has developed novel polymeric encapsulation and feedthrough technologies that are light enough to be implanted in small animals while still allowing the systems to function for time durations appropriate for the study of disease progression and treatment.
Noninvasive clinical trials
The lab is interested in noninvasive methods to electrically stimulate the vagus nerve. Noninvasive methods allow for quick clinical translation of new findings. The lab has developed a wireless over-the-ear device which is now being used to study the effects trans-auricular vagus nerve stimulation (TaVNS). Partnering with clinicians at Northwell Health, the lab is participating in a number of clinical trials looking at the effects of TaVNS.
Education
University of Maryland College Park, MD
Degree: BS
Field of study: Electrical engineering
2007
University of Maryland College Park, MD
Degree: MS
Field of study: Electrical engineering
2013
University of Maryland College Park, MD
Degree: PhD
Field of study: Electrical engineering
2015
Electrical engineering
2015
Honors & awards
2016 DARPA Program Leadership Award, Lawrence Livermore National Laboratory
2016 Engineering Directorate Award, Lawrence Livermore National Laboratory
2014 Circuits and Systems Society Travel Award, IEEE
2014 Student Travel Award, IEEE
2013 Graduate All-S.T.A.R. Fellow, University of Maryland
2012 School of Engineering Future Faculty Fellow, University of Maryland
2011 Qualcomm Innovation Fellowship Finalist
Publications
1. Transcutaneous auricular vagus nerve stimulation reduces pain and fatigue in patients with systemic lupus erythematosus: a randomised, double-blind, sham-controlled pilot trial, Aranow C., Atish-Fregoso Y, Lesser M, Mackay M, Anderson E, Chavan S, Zanos T, Datta-Chaudhuri T, Bouton C, Tracey K J, Diamond B, Annals of the Rheumatic Diseases, 2020.
2. Ultrasound powered piezoelectric neurostimulation devices: a commentary , Sun T, Wright J, Datta-Chaudhuri T, Bioelectronic Medicine, 2020.
3. Specific vagus nerve stimulation parameters alter serum cytokine levels in the absence of inflammation, Tsaava T, Datta-Chaudhuri T, Addorisio M E, Masi E B, Silverman H A, Newman J E, Imperato G H, Bouton C, Tracey K J, Chavan S S, Chang E H, Bioelectronic Medicine, 2020.
4. Quantitative estimation of nerve fiber engagement by vagus nerve stimulation using physiological markers , Chang YC, Cracchiolo M, Ahmed U, Mughrabi I, Gabalski A, Daytz A, Rieth L, Becker L, Datta-Chaudhuri T, Al-Abed Y, Zanos T, Zanos S, Brain Stimulation, 2020.
5. Anodal block permits directional vagus nerve stimulation , Ahmed U, Chang YC, Cracchiolo M, Lopez M, Tomaio J, Datta-Chaudhuri T, Zanos T, Rieth L, Al-Abed Y, Zanos S, Scientific Reports, 2020.
https://feinstein.northwell.edu/institutes-re...udhuri-phd
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