Heres an example of the issue I have
Here is a statement from the 2005-25 Sept shareholder letter
""Obtain biopsy tissue from patients with disease progression enrolling in the rollover protocol to correlate PD-L1 levels and changes in the tumor microenvironment on tumor tissue with PD-L1 expression on concurrently drawn CTCs"
I want to know how pdl1 levels between tumor biopsy and liquid biopsy typically correlate
A *search* said (im not posting it all, i started not to even make this post)
"Concerns about concordance: Other studies show that some liquid biopsy assays (like LDTs, or laboratory-developed tests) **may be discordant and could underestimate high PD-L1 positivity compared to tissue biopsy with established assays like 22C3"
Maybe its wrong and maybe its right. ( i hope its right!)
Perhaps someone smarter of more willing to dive into multiple papers can answer
I mean dont get me wrong. Im no fan of future AI. (I actually dont use a program. I just type into google like I have for years.)
But its hard to not use it.
Here is a statement from the 2005-25 Sept shareholder letter
""Obtain biopsy tissue from patients with disease progression enrolling in the rollover protocol to correlate PD-L1 levels and changes in the tumor microenvironment on tumor tissue with PD-L1 expression on concurrently drawn CTCs"
I want to know how pdl1 levels between tumor biopsy and liquid biopsy typically correlate
A *search* said (im not posting it all, i started not to even make this post)
"Concerns about concordance: Other studies show that some liquid biopsy assays (like LDTs, or laboratory-developed tests) **may be discordant and could underestimate high PD-L1 positivity compared to tissue biopsy with established assays like 22C3"
Maybe its wrong and maybe its right. ( i hope its right!)
Perhaps someone smarter of more willing to dive into multiple papers can answer
I mean dont get me wrong. Im no fan of future AI. (I actually dont use a program. I just type into google like I have for years.)
But its hard to not use it.
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