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Excerpt: "...In summary, our study provides eviden

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Post# of 158771
(Total Views: 544)
Posted On: 11/11/2025 11:17:07 AM
Posted By: dfwl28
Re: twinter11 #158403
Excerpt: "...In summary, our study provides evidence of antigen-specific clonal expansion of brain CD8+ T cells even at the early stage of amyloid pathology and elucidates their dynamic functional transition during AD progression through interactions with other brain immune cells. CD8+ T cells infiltrating the brain respond to the local environment, undergo clonal expansion, and express TCRs associated with amyloid pathology, promoting Aβ aggregation in an antigen-specific manner. This process involves effector CD8+ T cells modulating microglial reactivity via the CCL5-CCR5 signaling pathway. "

https://www.nature.com/articles/s41467-025-64503-x

Whenever I see the word "modulate" in a science paper, in conjunction with the CCR5/CCL5 axis I am encouraged and refreshed by science. The word cytodyn doesn't appear anywhere in such texts but I definitely sense its presence.



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