Role of the CCR5 Receptor in Neuropathic Pain Modu
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Posted On: 11/01/2025 9:59:11 PM
Role of the CCR5 Receptor in Neuropathic Pain Modulation: Current Insights and Therapeutic Implications
The Role of the CCR5 Receptor in Neuropathic Pain Modulation: Current Insights and Therapeutic Implications https://share.google/0uP9UTAJ3u0Y7lLWy
It's a pretty long read!
..."Conclusions
CCR5 has emerged as a critical mediator of neuroinflammatory processes underlying the development and maintenance of neuropathic pain. Preclinical evidence from diverse rodent models demonstrates that CCR5 contributes to central sensitization through activation of glial cells and several neuronal populations, as well as peripheral sensitization through recruitment of immune cells to injured nerves and modulation of DRG neurons. Pharmacological antagonism, genetic deletion, or targeted knockdown of CCR5 alleviates mechanical allodynia, thermal hyperalgesia, and spontaneous pain behaviors, highlighting its pivotal role in pain pathophysiology"...
The Role of the CCR5 Receptor in Neuropathic Pain Modulation: Current Insights and Therapeutic Implications https://share.google/0uP9UTAJ3u0Y7lLWy
It's a pretty long read!
..."Conclusions
CCR5 has emerged as a critical mediator of neuroinflammatory processes underlying the development and maintenance of neuropathic pain. Preclinical evidence from diverse rodent models demonstrates that CCR5 contributes to central sensitization through activation of glial cells and several neuronal populations, as well as peripheral sensitization through recruitment of immune cells to injured nerves and modulation of DRG neurons. Pharmacological antagonism, genetic deletion, or targeted knockdown of CCR5 alleviates mechanical allodynia, thermal hyperalgesia, and spontaneous pain behaviors, highlighting its pivotal role in pain pathophysiology"...
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