Quote from Reddit The important phrase here mig
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Posted On: 10/15/2025 10:13:42 AM
Re: biloxiblues #157905
Quote from Reddit
The important phrase here might just be 'confirm the signal'. Dr L didn't say CYDY has to wait to the end of the trial(s) to get results of patients being treated for CRC or mTNBC, and analyze the data. The trials may take many months to conclude and a few more months to get the final results and p values. So, if CYDY is measuring the level of Leronlimab induced changes in patient PD-L1 every week, or every two weeks, we will know hopefully quite quickly, how soon the levels are rising. We don't have to wait for the end of the trial(s). This may be known say in 2-3 months. The rise in PD-L1 will be known, and confirm the mechanism of action , and ''confirm the signal' in the tumor microenvironment way before the end of the trial(s). The goal is to show that this is how Leronlimab works, this shows how cold tumors are turned to hot, and then become treatable by an ICI! In my opinion, this is the breakthrough that will bring a partner to the table to negotiate.
The important phrase here might just be 'confirm the signal'. Dr L didn't say CYDY has to wait to the end of the trial(s) to get results of patients being treated for CRC or mTNBC, and analyze the data. The trials may take many months to conclude and a few more months to get the final results and p values. So, if CYDY is measuring the level of Leronlimab induced changes in patient PD-L1 every week, or every two weeks, we will know hopefully quite quickly, how soon the levels are rising. We don't have to wait for the end of the trial(s). This may be known say in 2-3 months. The rise in PD-L1 will be known, and confirm the mechanism of action , and ''confirm the signal' in the tumor microenvironment way before the end of the trial(s). The goal is to show that this is how Leronlimab works, this shows how cold tumors are turned to hot, and then become treatable by an ICI! In my opinion, this is the breakthrough that will bring a partner to the table to negotiate.
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