I think part of the answer lies within the digital

I think part of the answer lies within the digital briefing book, or whatever it was called by Jay. They clearly knew something was up with ICI's going back a good ways, but they had to run preclinicals, track down patients, clean up Amarex data, fill in some blanks, and a variety of other things to be as sure as possible that it was what they thought it was, as well as to be prepared to submit a proper BTD request.