Ok, since I have been a stockbroker for 40 years a
Post# of 157743
(Total Views: 310)
Posted On: 10/07/2025 10:08:47 AM
Re: biloxiblues #157720
Ok, since I have been a stockbroker for 40 years and not a Doctor, I had to ask Gemini to explain this to me. If my Mother had Adderall, I would have been like Ohm!
The core reason for the difference in effect between leronlimab and maraviroc—specifically, leronlimab's demonstrated ability to "heat up" cold triple-negative breast cancer (TNBC) tumors by inducing PD-L1 expression—comes down to their fundamental difference in molecular structure, binding mechanism, and duration of action, which translates into different downstream immunomodulatory effects.
Both drugs are antagonists of the CCR5 receptor, but they are very different types of molecules:
Feature Leronlimab Maraviroc
Type Humanized Monoclonal Antibody (IgG4) Small Molecule Inhibitor
Binding Mechanism Binds to the external domain of the CCR5 receptor. Binds to an allosteric site within the transmembrane domain of CCR5.
Duration of Action Long half-life, allowing for weekly dosing (provides sustained blockade). Short half-life, requiring daily (or twice-daily) oral dosing.
PD-L1 Upregulation (in mTNBC) Observed: Clinical data shows leronlimab induces PD-L1 expression on circulating tumor cells in a high percentage of patients (e.g., 88% at doses ≥ 525mg/week), which correlates with enhanced response to Immune Checkpoint Inhibitors (ICIs). Not Clinically Observed in TNBC: While it shows anti-metastatic effects in pre-clinical models and immune-modulating effects in other cancers (like colorectal cancer, where it's combined with ICIs), it has not demonstrated the same reliable PD-L1 up-regulation in TNBC.
Export to Sheets
Key Differences Explaining the Effect in TNBC
Monoclonal Antibody vs. Small Molecule:
Leronlimab is a large monoclonal antibody. Its binding to the CCR5 receptor on the cell surface may induce a different conformational change than the small-molecule maraviroc, potentially activating unique intracellular signaling pathways that lead to PD-L1 upregulation. Preclinical data suggests CCR5 activity suppresses glycosylated PD-L1, and leronlimab-mediated inhibition increases total PD-L1.
Maraviroc is a small molecule that binds to an internal site of the receptor. While effective at blocking the CCR5 ligand (CCL5) and reducing metastasis, its binding may not trigger the necessary cascade to upregulate PD-L1 on the tumor cells or circulating tumor-associated cells in the same way.
Sustained vs. Pulsed Blockade:
Leronlimab's weekly dosing provides a prolonged, high-level blockade of the CCR5 receptor due to its long half-life. This sustained presence in the tumor microenvironment may be crucial for remodeling the immune landscape—a process that takes time—to shift the tumor from "cold" to "hot" and stabilize the resulting PD-L1 expression.
Maraviroc's short half-life requires more frequent dosing. The resulting CCR5 blockade may be more pulsed or less complete in the deep tumor tissue, potentially failing to reach the necessary threshold or duration to induce the sustained PD-L1 expression seen with leronlimab.
Specific Immunomodulation:
Leronlimab's action is associated with a reduction in factors linked to ICI resistance, such as sB7H3 and sTyro3, and a reduction in immunosuppressive cells like cancer-associated macrophage-like cells (CAMLs) and regulatory T cells (Tregs). This multifaceted immune remodeling is what is believed to prime the tumor for successful PD-L1 blockade. While maraviroc has shown to repolarize macrophages in other cancer models (like colorectal), it has not shown the same breadth of immune-priming effects, particularly PD-L1 induction, in TNBC clinical observations.
Conclusion on the Treatment Option
Yes, the data strongly suggests a novel and promising treatment strategy for mTNBC patients with cold tumors.
The clinical observations for leronlimab in metastatic TNBC are compelling:
Cold-to-Hot Conversion: Leronlimab treatment reliably induces PD-L1 expression in a high percentage of mTNBC patients.
Synergistic Effect: Patients who had this PD-L1 induction and subsequently received an Immune Checkpoint Inhibitor (ICI) showed significantly enhanced and long-term survival. In one cohort, all five patients who induced PD-L1 and received an ICI were still alive after a median of ∼60 months.
This suggests a therapeutic window: using leronlimab first to convert the tumor to a "hot" or "inflamed" state, making it sensitive to immunotherapy, and then following with an ICI (like pembrolizumab or atezolizumab) to capitalize on the increased PD-L1 expression.
However, it is essential to note that this is based on pooled data from earlier trials and retrospective analysis. Further prospective, randomized clinical trials are necessary to formally establish this sequential or combination approach as a standard-of-care treatment option for metastatic TNBC.
The core reason for the difference in effect between leronlimab and maraviroc—specifically, leronlimab's demonstrated ability to "heat up" cold triple-negative breast cancer (TNBC) tumors by inducing PD-L1 expression—comes down to their fundamental difference in molecular structure, binding mechanism, and duration of action, which translates into different downstream immunomodulatory effects.
Both drugs are antagonists of the CCR5 receptor, but they are very different types of molecules:
Feature Leronlimab Maraviroc
Type Humanized Monoclonal Antibody (IgG4) Small Molecule Inhibitor
Binding Mechanism Binds to the external domain of the CCR5 receptor. Binds to an allosteric site within the transmembrane domain of CCR5.
Duration of Action Long half-life, allowing for weekly dosing (provides sustained blockade). Short half-life, requiring daily (or twice-daily) oral dosing.
PD-L1 Upregulation (in mTNBC) Observed: Clinical data shows leronlimab induces PD-L1 expression on circulating tumor cells in a high percentage of patients (e.g., 88% at doses ≥ 525mg/week), which correlates with enhanced response to Immune Checkpoint Inhibitors (ICIs). Not Clinically Observed in TNBC: While it shows anti-metastatic effects in pre-clinical models and immune-modulating effects in other cancers (like colorectal cancer, where it's combined with ICIs), it has not demonstrated the same reliable PD-L1 up-regulation in TNBC.
Export to Sheets
Key Differences Explaining the Effect in TNBC
Monoclonal Antibody vs. Small Molecule:
Leronlimab is a large monoclonal antibody. Its binding to the CCR5 receptor on the cell surface may induce a different conformational change than the small-molecule maraviroc, potentially activating unique intracellular signaling pathways that lead to PD-L1 upregulation. Preclinical data suggests CCR5 activity suppresses glycosylated PD-L1, and leronlimab-mediated inhibition increases total PD-L1.
Maraviroc is a small molecule that binds to an internal site of the receptor. While effective at blocking the CCR5 ligand (CCL5) and reducing metastasis, its binding may not trigger the necessary cascade to upregulate PD-L1 on the tumor cells or circulating tumor-associated cells in the same way.
Sustained vs. Pulsed Blockade:
Leronlimab's weekly dosing provides a prolonged, high-level blockade of the CCR5 receptor due to its long half-life. This sustained presence in the tumor microenvironment may be crucial for remodeling the immune landscape—a process that takes time—to shift the tumor from "cold" to "hot" and stabilize the resulting PD-L1 expression.
Maraviroc's short half-life requires more frequent dosing. The resulting CCR5 blockade may be more pulsed or less complete in the deep tumor tissue, potentially failing to reach the necessary threshold or duration to induce the sustained PD-L1 expression seen with leronlimab.
Specific Immunomodulation:
Leronlimab's action is associated with a reduction in factors linked to ICI resistance, such as sB7H3 and sTyro3, and a reduction in immunosuppressive cells like cancer-associated macrophage-like cells (CAMLs) and regulatory T cells (Tregs). This multifaceted immune remodeling is what is believed to prime the tumor for successful PD-L1 blockade. While maraviroc has shown to repolarize macrophages in other cancer models (like colorectal), it has not shown the same breadth of immune-priming effects, particularly PD-L1 induction, in TNBC clinical observations.
Conclusion on the Treatment Option
Yes, the data strongly suggests a novel and promising treatment strategy for mTNBC patients with cold tumors.
The clinical observations for leronlimab in metastatic TNBC are compelling:
Cold-to-Hot Conversion: Leronlimab treatment reliably induces PD-L1 expression in a high percentage of mTNBC patients.
Synergistic Effect: Patients who had this PD-L1 induction and subsequently received an Immune Checkpoint Inhibitor (ICI) showed significantly enhanced and long-term survival. In one cohort, all five patients who induced PD-L1 and received an ICI were still alive after a median of ∼60 months.
This suggests a therapeutic window: using leronlimab first to convert the tumor to a "hot" or "inflamed" state, making it sensitive to immunotherapy, and then following with an ICI (like pembrolizumab or atezolizumab) to capitalize on the increased PD-L1 expression.
However, it is essential to note that this is based on pooled data from earlier trials and retrospective analysis. Further prospective, randomized clinical trials are necessary to formally establish this sequential or combination approach as a standard-of-care treatment option for metastatic TNBC.
(4)
(0)