"CCR5 isn't just HIV or cancer. It's an immune swi
Post# of 157598
(Total Views: 530)
Posted On: 09/18/2025 3:19:11 PM
"CCR5 isn't just HIV or cancer. It's an immune switch..."
Kat--just to take your big picture comments a little further--I've started to think about the CCR5 receptor as perhaps the single biggest weak spot or weak link in human biology/physiology. HIV uses it as a co-receptor, cancer manipulates it to metastasize and hide from the immune system... and when it is dysregulated because of environmental factors and age you get chronic conditions like atherosclerosis and Alzheimers. At scale, if developed for just these conditions, millions of lives saved, millions of lives changed.
Leronlimab might become the most life-saving drug in history! And yet people are starting to whine about the delays and the share price. Lordy--just name me one other penny stock with such incredible news in the last calendar year. Name any Big Pharma with such ground-breaking news for that matter! And with clinical trials moving right along we are about to prove it with the most valuable currency in biotech--DATA. The kind of unimpeachable data Lalezari knows we need to satisfy the suits on Wall Street. I am content to patiently wait... because I believe in the science and in the deliberate, comprehensive path of development Cytodyn is currently taking with the drug (given the financial limitations we are working under).
Wouldn't you love to sit down for lunch with Paul Maddon? (If the name is unfamiliar, he is the gentleman who developed PRO-140). Before its all said and done I wonder if he'll win a Nobel Prize? Dr Lalezari too, making the connection with leronlimab and the upregulation of PD-L1 in cancer. Saving lives is probably reward enough for those guys... But it would be nice to see brilliance and determination receiving there just tribute on the world stage.
Kat--just to take your big picture comments a little further--I've started to think about the CCR5 receptor as perhaps the single biggest weak spot or weak link in human biology/physiology. HIV uses it as a co-receptor, cancer manipulates it to metastasize and hide from the immune system... and when it is dysregulated because of environmental factors and age you get chronic conditions like atherosclerosis and Alzheimers. At scale, if developed for just these conditions, millions of lives saved, millions of lives changed.
Leronlimab might become the most life-saving drug in history! And yet people are starting to whine about the delays and the share price. Lordy--just name me one other penny stock with such incredible news in the last calendar year. Name any Big Pharma with such ground-breaking news for that matter! And with clinical trials moving right along we are about to prove it with the most valuable currency in biotech--DATA. The kind of unimpeachable data Lalezari knows we need to satisfy the suits on Wall Street. I am content to patiently wait... because I believe in the science and in the deliberate, comprehensive path of development Cytodyn is currently taking with the drug (given the financial limitations we are working under).
Wouldn't you love to sit down for lunch with Paul Maddon? (If the name is unfamiliar, he is the gentleman who developed PRO-140). Before its all said and done I wonder if he'll win a Nobel Prize? Dr Lalezari too, making the connection with leronlimab and the upregulation of PD-L1 in cancer. Saving lives is probably reward enough for those guys... But it would be nice to see brilliance and determination receiving there just tribute on the world stage.
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