Quite a fascinating, well engineered line of inqui
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Posted On: 08/08/2025 12:22:53 PM
Quite a fascinating, well engineered line of inquiry in a multi-year study on Alzheimer’s Disease demonstrating the importance of lithium in neuronal function the absence of which is demonstrated to be associated with AD and cognitive decline.
https://www.nature.com/articles/s41586-025-09335-x#Fig4
Notice in particular figure 4 and the cascading up-regulation of pro-inflammatory cytokines. More grist for the mill for whomever chooses to partner or buy out Cytodyn.
“Microglia from Li-deficient wild-type mice showed elevated release of the pro-inflammatory cytokines IL-6, TNF and G-CSF, as well as the immune activating chemokines CCL3, CCL4, CCL5 and CXCL2 (Fig. 4d). Finally, microglia isolated from Li-deficient wild-type mice showed significantly reduced Aβ42 uptake and subsequent degradation of Aβ42 relative to microglia from control mice (Fig. 4e). Thus, Li deficiency leads to a reactive pro-inflammatory state and impaired Aβ clearance.”
https://www.nature.com/articles/s41586-025-09335-x#Fig4
Notice in particular figure 4 and the cascading up-regulation of pro-inflammatory cytokines. More grist for the mill for whomever chooses to partner or buy out Cytodyn.
“Microglia from Li-deficient wild-type mice showed elevated release of the pro-inflammatory cytokines IL-6, TNF and G-CSF, as well as the immune activating chemokines CCL3, CCL4, CCL5 and CXCL2 (Fig. 4d). Finally, microglia isolated from Li-deficient wild-type mice showed significantly reduced Aβ42 uptake and subsequent degradation of Aβ42 relative to microglia from control mice (Fig. 4e). Thus, Li deficiency leads to a reactive pro-inflammatory state and impaired Aβ clearance.”
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