Is it that the CD4+ cells are the hidden viral res

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Is it that the CD4+ cells are the hidden viral reservoir/repository for the HIV virus, and Leron upregulates them and thus makes them "hot," just as it turns tumors hot in TNBC?

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I'll try to simplify it a bit.

Leronlimab and HIV reservoirs

Leronlimab in the long run downregulates IFNy, TNF-a and NF-kb ( proteins that are responsible for increasing inflammatory cytokines). That downregulation seems to be associated with a large increase in CD4+ cells. However for a few hours after the initial binding of leronlimab there would be a significant increase in them all. IFNy increases TNF-a which in turn increases NF-kb. NF-kb is the important one here. One of the things that NF-kb does is induce DNA/RNA replication including that of the HIV virus in viral reservoirs which then clears the reservoirs. It's not 100% efficient but it will clear many of them.

Leronlimab and the increase in PD-L1

Leronlimab by increasing IFNy temporarily activates the IFNy/JAK/STAT pathway which activates PD-L1 expression. Same IFNy starting point as the clearance of HIV reservoirs but different pathways.