Correction: As Misui rightly pointed out, 50% of t
Post# of 154646
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Posted On: 06/28/2025 1:46:38 PM
Re: Evil Rabbit #154630
Correction: As Misui rightly pointed out, 50% of the patients in the trial will be on 350mg and the other 50% on 700mg.
Also, the 350mg may get upped if the DSMB recommends as much, but those 30 patients on 700mg should give us some fantastic results.
Buddyboy added more detail too:
"it is the first five patients at 350mg dosage. Then, if the DSMB doesn't see any issues, they will go to the two arm study (half at 350mg, half at 700mg). The DSMB is supposed to take a look at the first 20 patients in the two arm study. At that time the DSMB can advise to restrict the dosing to one amount. If they deem it necessary.”
I gotta think there WILL be a difference in data between 350 and 700 and unless there’s DSMB sabotage everyone will be given 700mg. Too optimistic? Time will tell.
Also, the 350mg may get upped if the DSMB recommends as much, but those 30 patients on 700mg should give us some fantastic results.
Buddyboy added more detail too:
"it is the first five patients at 350mg dosage. Then, if the DSMB doesn't see any issues, they will go to the two arm study (half at 350mg, half at 700mg). The DSMB is supposed to take a look at the first 20 patients in the two arm study. At that time the DSMB can advise to restrict the dosing to one amount. If they deem it necessary.”
I gotta think there WILL be a difference in data between 350 and 700 and unless there’s DSMB sabotage everyone will be given 700mg. Too optimistic? Time will tell.
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