In the 5/13/25 PR which detailed the results from
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Posted On: 06/26/2025 2:52:40 AM
In the 5/13/25 PR which detailed the results from the old mTNBC trials, Dr. Lalezari said:
"We have also amended our current colorectal cancer trial to ensure the prospective collection of PD-L1 data in a second type of solid tumor.”
I checked the protocol on clinicaltrials.gov and could find no mention of this. There was also no mention of treating trial patients with an ICI if there was an increase in PD-L1 levels. Does anyone have a reference to any statements by CYDY that this would be done?
My hope/fantasy is that during the trial, in (hopefully most) patients whose PD-L1 elevates and who are then dosed with an ICI, that tumors start shrinking and disappearing and the DSMB is forced to recommend early approval for this treatment regimen. Whereupon we can all retire rich and happy!
Ganesha
"We have also amended our current colorectal cancer trial to ensure the prospective collection of PD-L1 data in a second type of solid tumor.”
I checked the protocol on clinicaltrials.gov and could find no mention of this. There was also no mention of treating trial patients with an ICI if there was an increase in PD-L1 levels. Does anyone have a reference to any statements by CYDY that this would be done?
My hope/fantasy is that during the trial, in (hopefully most) patients whose PD-L1 elevates and who are then dosed with an ICI, that tumors start shrinking and disappearing and the DSMB is forced to recommend early approval for this treatment regimen. Whereupon we can all retire rich and happy!
Ganesha 
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