World-first "undruggable" cancer treatment enters
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Posted On: 06/16/2025 7:16:03 AM
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World-first "undruggable" cancer treatment enters human trial
“Approximately 70% of all cancers are fueled by abnormal MYC activity,” said hematologist and ANU professor Mark Polizzotto. “MYC is one of the most notorious cancer-causing genes, and tumors driven by MYC overexpression are often among the most aggressive and difficult to treat."
Myc enhances cell division leading to tumor growth. The mTOR pathway upregulates Myc expression and both are activated by CCR5. Leronlimab downregulates both. mTOR is also involved in ATP production which increases the energy conversion needed for cell division and leronlimab also downregulates ATP. On top of that leronlimab downregulates VEGF that increases blood vessel growth (angiogenesis) necessary for the support of cell division. If that's not enough there's leronlimab's disruption of the mTOR/PI3K/AKT/EIF4E pathway. EIF4E is essential to cell division.
So I think leronlimab has quite a few more things going for it than an anti-Myc drug.
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