Overall Survival and Quality-of-Life Superiority i

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In this meta-epidemiological study, across 791 trials, 53% of trials were interpreted as showing primary end-point superiority; however, overall survival and quality-of-life superiority were shown in just 28% and 11% of trials, respectively. In 32% of trials, superiority of either overall survival or quality of life was demonstrated; in 6%, both were shown.

Meaning: Although phase 3 trials are often interpreted as demonstrating superiority, overall survival and quality of life, which may be the most relevant end points to patients, are uncommonly improved.

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