Humanized mouse blood vessel data --- while we now
Post# of 153807
(Total Views: 2516)
Posted On: 05/25/2025 2:11:22 AM
Humanized mouse blood vessel data --- while we now wait for the human data:
@ botton about 3 paragraphs before Patent Citations --- Outstanding P-v's too:
The number of blood vessels was expressed based on total vessel area, vessel length density, and vessel diameter.
(b) Results: Quantitative analyses of blood vessels directly feeding into day 10 SW480 colon carcinoma tumors inoculated in the dermis of the flanks revealed a significant decrease in the number of vessels in tumors from leronlimab-treated humanized mice compared with IgG-treated hosts (FIG. 19A), consistent with leronlimab causing an inhibitory effect on neoangiogenesis in the tumor bed.
The utilization of VESGEN software allowed detailed comparisons between treatment groups and revealed marked reduction in multiple key properties of the vascular network feeding the tumor, including
62% reduction in total vessel area (pixels) (p=0.013),
53% reduction in vessel length density (p=0.0011),
61% reduction in number of large vessels (p=0.0082),
and 80% reduction in number of small vessels (p=0.017),
https://patents.google.com/patent/WO2021026028A1/en
___
"...inhibitory effect on neoangiogenesis in the tumor bed."
@ botton about 3 paragraphs before Patent Citations --- Outstanding P-v's too:
The number of blood vessels was expressed based on total vessel area, vessel length density, and vessel diameter.
(b) Results: Quantitative analyses of blood vessels directly feeding into day 10 SW480 colon carcinoma tumors inoculated in the dermis of the flanks revealed a significant decrease in the number of vessels in tumors from leronlimab-treated humanized mice compared with IgG-treated hosts (FIG. 19A), consistent with leronlimab causing an inhibitory effect on neoangiogenesis in the tumor bed.
The utilization of VESGEN software allowed detailed comparisons between treatment groups and revealed marked reduction in multiple key properties of the vascular network feeding the tumor, including
62% reduction in total vessel area (pixels) (p=0.013),
53% reduction in vessel length density (p=0.0011),
61% reduction in number of large vessels (p=0.0082),
and 80% reduction in number of small vessels (p=0.017),
https://patents.google.com/patent/WO2021026028A1/en
___
"...inhibitory effect on neoangiogenesis in the tumor bed."
(7)
(0)