CassandraX— I’ve been noticing in the scien
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Posted On: 05/14/2025 5:43:43 AM
Re: Cassandra X #152323
CassandraX—
I’ve been noticing in the scientific literature the use of the phrase “CCR5/CCL5 Axis” when talking about the blockade/inhibition of the CCR5 receptor. I think this is a way of emphasizing the complexity of immune signaling and it’s contingent, reactive nature in human disease. Your persistent (and lengthy!) interrogation of ChatGPT about CCR5 expression and CCL5 signaling really made this explicit. I found it both fascinating and frustrating—frustrating because there are huge gaps in our knowledge of the immune system and ChatGPT can’t tell us what we, as a scientific community, don’t know…
Ohm has a handle on this more than most, and his emphasis on “homeostasis” has been very helpful to me in grasping a hint of the contingency and complexity of all this. His comment in a post a few days ago about a CC5 receptor “retreating” into a cell just blew my mind. I didn’t know receptors do that! And of course, if they can retreat that implies they can also emerge from a cell. And then I couldn’t help but trying to visualize what that might look like… But I digress.)
I wonder if the promotion of homeostasis by leronlimab is one reason we have what appear to be cures in mTNBC? If that makes any sense…
Well Cassandra, the emphasis in your post about CCL5 signaling made me think we should probably be paying more attention to that side of the equation. I recall a comment by Bruce Patterson, back in 2020 TED TALK I believe, who famously said “Covid-19 was a RANTES disease…”
What if metastasis turns out to be a RANTES disease? What if atherosclerosis is a RANTES disease? Fibrosis? AD?
While I don’t have access to ChatGPT, when I google CCR5 questions they often provide an “AI Overview” that digs into the topic a bit. Just for kicks I asked if metastasis is a RANTES disease, and ditto for atherosclerosis. Predictably, Google AI said “No, metastasis is not a RANTES disease” but went on to say its a chemokine that plays a role in cancer progression and metastasis. We know that! But I was a little surprised when I got the following about gunk clogging up the arteries:
"Yes, atherosclerosis is often referred to as a RANTES disease, as the chemokine RANTES (Regulated on activation, normal T cell expressed and secreted) plays a significant role in its development and progression. RANTES is involved in recruiting inflammatory cells to the artery walls, contributing to the formation of atherosclerotic plaques."
Surprisingly, google AI didn’t mention that RANTES “enhances immune cell adhesion to the endothelium,” which contributes to atherosclerosis… and ChatGPT did (in Cassandra’s post). Score one for ChatGPT!
Well, I’ve been thinking about the post for a few days now and wanted to respond before it was forgotten in the rush of what could be great news soon! Fascinating stuff Cassandra.
Sherlock57
I’ve been noticing in the scientific literature the use of the phrase “CCR5/CCL5 Axis” when talking about the blockade/inhibition of the CCR5 receptor. I think this is a way of emphasizing the complexity of immune signaling and it’s contingent, reactive nature in human disease. Your persistent (and lengthy!) interrogation of ChatGPT about CCR5 expression and CCL5 signaling really made this explicit. I found it both fascinating and frustrating—frustrating because there are huge gaps in our knowledge of the immune system and ChatGPT can’t tell us what we, as a scientific community, don’t know…
Ohm has a handle on this more than most, and his emphasis on “homeostasis” has been very helpful to me in grasping a hint of the contingency and complexity of all this. His comment in a post a few days ago about a CC5 receptor “retreating” into a cell just blew my mind. I didn’t know receptors do that! And of course, if they can retreat that implies they can also emerge from a cell. And then I couldn’t help but trying to visualize what that might look like… But I digress.)
I wonder if the promotion of homeostasis by leronlimab is one reason we have what appear to be cures in mTNBC? If that makes any sense…
Well Cassandra, the emphasis in your post about CCL5 signaling made me think we should probably be paying more attention to that side of the equation. I recall a comment by Bruce Patterson, back in 2020 TED TALK I believe, who famously said “Covid-19 was a RANTES disease…”
What if metastasis turns out to be a RANTES disease? What if atherosclerosis is a RANTES disease? Fibrosis? AD?
While I don’t have access to ChatGPT, when I google CCR5 questions they often provide an “AI Overview” that digs into the topic a bit. Just for kicks I asked if metastasis is a RANTES disease, and ditto for atherosclerosis. Predictably, Google AI said “No, metastasis is not a RANTES disease” but went on to say its a chemokine that plays a role in cancer progression and metastasis. We know that! But I was a little surprised when I got the following about gunk clogging up the arteries:
"Yes, atherosclerosis is often referred to as a RANTES disease, as the chemokine RANTES (Regulated on activation, normal T cell expressed and secreted) plays a significant role in its development and progression. RANTES is involved in recruiting inflammatory cells to the artery walls, contributing to the formation of atherosclerotic plaques."
Surprisingly, google AI didn’t mention that RANTES “enhances immune cell adhesion to the endothelium,” which contributes to atherosclerosis… and ChatGPT did (in Cassandra’s post). Score one for ChatGPT!
Well, I’ve been thinking about the post for a few days now and wanted to respond before it was forgotten in the rush of what could be great news soon! Fascinating stuff Cassandra.
Sherlock57
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