Not sure if they ever disclosed receptor occupancy
Post# of 152558
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Posted On: 05/07/2025 7:13:41 AM
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Not sure if they ever disclosed receptor occupancy versus dosage or LL concentration curve, have they?
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Finally, we extended these results to Leronlimab-treated humans and found that weekly 700 mg Leronlimab led to complete CCR5 RO on peripheral blood CD4+ T cells and a statistically significant increase in CCR5+CD4+ T cells in peripheral blood.
https://pubmed.ncbi.nlm.nih.gov/34868084/
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We observed complete CCR5 receptor occupancy in all donors by day 7.https://www.ijidonline.com/article/S1201-9712(20)32305-5/pdf
Until 2019 there wasn't a sensitive enough test to accurately determine CCR5 receptor occupancy. Patterson developed a flow cytometry one for Cytodyn.
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