PEMF continues to impress researchers
Pulsed electromagnetic fields treatment ameliorates cardiac function after myocardial infarction in mice and pigs
Journal of Advanced Research
16 April 2025
• PEMF treatment can ameliorate cardiac function and reduce scar size in post-MI mice and pigs.
• The benefits of PEMF in the treatment of MI are supported by reduced inflammatory responses, improved cell survival, and decreased collagen secretion.
• The underlying molecular mechanism of PEMF treatment is associated with the inhibition of the TLR4/MyD88/NF-κB and TGF-β1/SMAD3 signaling pathways.
• From the perspective of safety, the process of PEMF treatment is safe. No adverse events occur. PEMF treatment does not cause damage to liver or kidney function and does not lead to the growth of harmful intestinal flora.
• PEMF treatment holds significant promise as a noninvasive physical therapy modality, justifying further exploration of its potential implications for managing patients with IHD.
https://www.sciencedirect.com/science/article...3225002632
Regulation of Inflammatory Responses by Pulsed Electromagnetic Fields
Warren Alpert Medical School of Brown University
Published: 30 April 2025
"PEMFs are in wide use for enhancing bone repair in fracture non-unions, but until relatively recently, the mechanism of membrane signal transduction has been obscure. The observation that PEMFs stimulate adenosine receptors and act as an agonist to the A2A receptor has led to a substantially improved the mechanistic understanding of PEMF signal transduction and also a consideration of the effects of PEMF therapy on tissues and molecules other than in the skeleton. This series clarifies the biological effects of PEMF therapy in a number of model systems and should enhance confidence in the mechanistic understanding of PEMF effects clinically. Preclinical and preliminary clinical studies suggest that PEMFs have a spectrum of biological actions including the suppression of inflammation and enhancement of soft tissue repair."
https://www.mdpi.com/2306-5354/12/5/474
Pulsed electromagnetic field ameliorates the progression of osteoarthritis via the Sirt1/NF-κB pathway , Arthritis Research & Therapy, Published: 14 February 2025
"PEMF inhibited IL-1β-mediated the expression of pro-inflammatory factors. Besides, PEMF alleviated IL-1β-induced degradation of ECM by increasing the expression of Col2a1 and ACAN, while inhibiting the expression of MMP13 and ADAMTS5. At the mechanism level, PEMF increased the expression of Sirt1 and inhibited IL-1β-induced the activation of NF-κB pathway. Furthermore, blocking Sirt1 with EX-527 attenuated the effect of PEMF on the inhibition of NF-κB pathway and the expression of ECM in IL-1β-induced chondrocytes. In vivo, PEMF-treated OA mice showed low modified mankin scores, reduced the number of osteophytes and preserved joint structure."
"Our results suggest that PEMF inhibits NF-κB pathway and blocks the expression of inflammatory factors by activating the expression of Sirt1, which may be a novel strategy for OA."
https://arthritis-research.biomedcentral.com/...25-03492-0
Pulsed electromagnetic fields treatment ameliorates cardiac function after myocardial infarction in mice and pigs
Journal of Advanced Research
16 April 2025
• PEMF treatment can ameliorate cardiac function and reduce scar size in post-MI mice and pigs.
• The benefits of PEMF in the treatment of MI are supported by reduced inflammatory responses, improved cell survival, and decreased collagen secretion.
• The underlying molecular mechanism of PEMF treatment is associated with the inhibition of the TLR4/MyD88/NF-κB and TGF-β1/SMAD3 signaling pathways.
• From the perspective of safety, the process of PEMF treatment is safe. No adverse events occur. PEMF treatment does not cause damage to liver or kidney function and does not lead to the growth of harmful intestinal flora.
• PEMF treatment holds significant promise as a noninvasive physical therapy modality, justifying further exploration of its potential implications for managing patients with IHD.
https://www.sciencedirect.com/science/article...3225002632
Regulation of Inflammatory Responses by Pulsed Electromagnetic Fields
Warren Alpert Medical School of Brown University
Published: 30 April 2025
"PEMFs are in wide use for enhancing bone repair in fracture non-unions, but until relatively recently, the mechanism of membrane signal transduction has been obscure. The observation that PEMFs stimulate adenosine receptors and act as an agonist to the A2A receptor has led to a substantially improved the mechanistic understanding of PEMF signal transduction and also a consideration of the effects of PEMF therapy on tissues and molecules other than in the skeleton. This series clarifies the biological effects of PEMF therapy in a number of model systems and should enhance confidence in the mechanistic understanding of PEMF effects clinically. Preclinical and preliminary clinical studies suggest that PEMFs have a spectrum of biological actions including the suppression of inflammation and enhancement of soft tissue repair."
https://www.mdpi.com/2306-5354/12/5/474
Pulsed electromagnetic field ameliorates the progression of osteoarthritis via the Sirt1/NF-κB pathway , Arthritis Research & Therapy, Published: 14 February 2025
"PEMF inhibited IL-1β-mediated the expression of pro-inflammatory factors. Besides, PEMF alleviated IL-1β-induced degradation of ECM by increasing the expression of Col2a1 and ACAN, while inhibiting the expression of MMP13 and ADAMTS5. At the mechanism level, PEMF increased the expression of Sirt1 and inhibited IL-1β-induced the activation of NF-κB pathway. Furthermore, blocking Sirt1 with EX-527 attenuated the effect of PEMF on the inhibition of NF-κB pathway and the expression of ECM in IL-1β-induced chondrocytes. In vivo, PEMF-treated OA mice showed low modified mankin scores, reduced the number of osteophytes and preserved joint structure."
"Our results suggest that PEMF inhibits NF-κB pathway and blocks the expression of inflammatory factors by activating the expression of Sirt1, which may be a novel strategy for OA."
https://arthritis-research.biomedcentral.com/...25-03492-0
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