I’ve been meaning to bring a question to the boa

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I’ve been meaning to bring a question to the board for a bit. Does anyone have an informed opinion about mRNA vaccines that are being studied to prevent mTNBC. (I think in Ph1 for dose escalation in small N)

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mRNA-4359's mechanism of action is to induce the immune system itself to produce T-cells that will target PD-L1 and IDO-1 expressing tumor cells and kill them. It may be very effective at doing so. The possible complications are that there are other Tregs that downregulate T-cell expression and would reduce the effectiveness. The other downside is that some tumor cells may have mutations where the drug will have no effect and they then become the predominate tumor cells or tumor cells can mutate in response to avoid detection. Leronlimab by boosting killer T-cell counts alongside the other anti-tumor responses might boost mRNA-4359's effectiveness, Then again maybe not. Leronlimab knocks down PD-L1 and IDO-1 is upregulated by IFN-y so leronlimab most likely downregulates that also by downregulating IFN-y. So leronlimab already strips away tumor cell defenses while boosting T-cells and etc. so it may be superior to a combo of the two.