Ohm, do these indicate that CCR5 can help with Wes

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Ohm, do these indicate that CCR5 can help with West Nile Virus and Hantavirus, what Betsy Arakawa died from?

Δ ccr5 Genotype Is Associated with Mild Form of Nephropathia Epidemica

CCR5 deficiency increases risk of symptomatic West Nile virus infection

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The CCR5 delta 32 deletion has similarities to CCR5 blockade but there are broad differences. With delta 32 the other CCR and CXCR receptors would have genetically altered to increase their number and binding efficacy to make up for the loss of CCR5. Without that change the hosts would die out along with the genetic variation. CCR5 delta 32 deletion simply switches immune response to the other receptors although a bit weaker.

Nephropathia Epidemica is a low level form of hantavirus and that study shows that the CCR5 delta 32 deletion produces milder symptoms (due to the slightly weaker response from the other receptors). The hantavirus causes cellular damage and induces a cytokine storm that can cause endothelium permeability which is where the hemorrhaging occurs. Hantaviruses also knock down killer T-cell (M1 macrophages) counts as do most viruses. Leronlimab would quell the cytokine storm and reverse the lowered T-cell counts by the M2 to M1 macrophage switch thus the immune system can effectively fight the virus.

In the case of West Nile virus, CCR5 delta 32 deletion actually makes it worse. As with the hantavirus you see a massive rise in cytokines and lowered killer T-cells. The West Nile virus can also curb antibody response to the virus. With the delta 32 deletion and a weaker overall response from the other receptors to a very tough virus it's no wonder you'd see a bit worse death toll. You also don't get the advantage of the M2 to M1 polarization and the drastic curbing of cytokines as you do with leronlimab.