Microbiome modulation of implant-related infection by a novel miniaturized pulsed electromagnetic field device
João Gabriel S. Souza, Fabio Azevedo, Maria Helena Rossy Borges, Raphael Cavalcante Costa, Takahiko Shiba, Shlomo Barak, Yaniv Mayer, Luciene Cristina de Figueiredo, Magda Feres, Valentim A. R. Barão & Jamil A. Shibli
Published: 26 February 2025
"Dental implant-related infections, which lack effective therapeutic strategies, are considered the primary cause for treatment failure. Pulsed electromagnetic field (PEMF) technology has been introduced as a safe and effective modality for enhancing biological responses. However, the PEMF effect on modulating microbial diversity has not been explored. Thus, we tested a miniaturized PEMF biomedical device as a healing component for dental implants. PEMF activation did not alter the chemical composition, surface roughness, wettability, and electrochemical performance. PEMF effectively controlled chronic in vitro polymicrobial microbial accumulation. The in vivo study where devices were inserted in the patients’ oral cavities and 16S RNA sequencing analysis evidenced a fivefold or more reduction in 23 bacterial species for PEMF group and the absence of some species for this group, including pathogens associated with implant-related infections. PEMF altered bacterial interactions and promoted specific bacterial pathways. PEMF has emerged as an effective strategy for controlling implant-related infections."
https://www.nature.com/articles/s41522-025-00667-0
João Gabriel S. Souza, Fabio Azevedo, Maria Helena Rossy Borges, Raphael Cavalcante Costa, Takahiko Shiba, Shlomo Barak, Yaniv Mayer, Luciene Cristina de Figueiredo, Magda Feres, Valentim A. R. Barão & Jamil A. Shibli
Published: 26 February 2025
"Dental implant-related infections, which lack effective therapeutic strategies, are considered the primary cause for treatment failure. Pulsed electromagnetic field (PEMF) technology has been introduced as a safe and effective modality for enhancing biological responses. However, the PEMF effect on modulating microbial diversity has not been explored. Thus, we tested a miniaturized PEMF biomedical device as a healing component for dental implants. PEMF activation did not alter the chemical composition, surface roughness, wettability, and electrochemical performance. PEMF effectively controlled chronic in vitro polymicrobial microbial accumulation. The in vivo study where devices were inserted in the patients’ oral cavities and 16S RNA sequencing analysis evidenced a fivefold or more reduction in 23 bacterial species for PEMF group and the absence of some species for this group, including pathogens associated with implant-related infections. PEMF altered bacterial interactions and promoted specific bacterial pathways. PEMF has emerged as an effective strategy for controlling implant-related infections."
https://www.nature.com/articles/s41522-025-00667-0
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